ID A0A063BLU0_9BURK Unreviewed; 435 AA.
AC A0A063BLU0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Ureidoglycolate lyase {ECO:0000256|ARBA:ARBA00019751};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
DE EC=4.3.2.3 {ECO:0000256|ARBA:ARBA00012341};
DE AltName: Full=Ureidoglycolase {ECO:0000256|ARBA:ARBA00032843};
DE AltName: Full=Ureidoglycolatase {ECO:0000256|ARBA:ARBA00030302};
DE AltName: Full=Ureidoglycolate hydrolase {ECO:0000256|ARBA:ARBA00029968};
GN ORFNames=LIG30_1870 {ECO:0000313|EMBL:KDB09118.1};
OS Burkholderia sp. lig30.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=1192124 {ECO:0000313|EMBL:KDB09118.1, ECO:0000313|Proteomes:UP000027020};
RN [1] {ECO:0000313|EMBL:KDB09118.1, ECO:0000313|Proteomes:UP000027020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LIG30 {ECO:0000313|Proteomes:UP000027020};
RA Woo H.L., Utturkar S.M., Klingeman D.M., Simmons B.A., DeAngelis K.M.,
RA Brown S.D., Hazen T.C.;
RT "Draft Genome of the Lignin-degrading Burkholderia sp. Strain LIG30,
RT Isolated from Wet Tropical Forest Soil.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001281};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
CC -!- PATHWAY: Purine metabolism; urate degradation.
CC {ECO:0000256|ARBA:ARBA00004705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDB09118.1}.
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DR EMBL; JGVW01000061; KDB09118.1; -; Genomic_DNA.
DR RefSeq; WP_038711091.1; NZ_JGVW01000061.1.
DR AlphaFoldDB; A0A063BLU0; -.
DR STRING; 1192124.LIG30_1870; -.
DR PATRIC; fig|1192124.4.peg.1649; -.
DR eggNOG; COG0179; Bacteria.
DR OrthoDB; 3766879at2; -.
DR UniPathway; UPA00139; UER00341.
DR UniPathway; UPA00394; -.
DR Proteomes; UP000027020; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KDB09118.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000027020};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 32..135
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 142..411
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 435 AA; 46646 MW; E57EE9B32679EC52 CRC64;
MSATPDWRVT LDPARKSWLD TANDPACDFP IQNLPSGIFS DAKQPARRAG VALGDQIVDL
AALARAGLVT LPAGAGNVFD APSLNAFIAL GRDAWRSVRV QLSALFARDT ARLRDDAALR
AQALVPQRGA TLHLPVEIPG YTDFYSSKEH ATNVGSMFRD PKNALLPNWS EMPIGYNGRA
SSVVVSGTPV RRPNGQLKAP DQERPVFGAC RKLDIELETG FVVGQGNALG EPIACGDAEA
HIFGMVLLND WSARDIQQWE YVPLGPFNAK TFATTISPWI VTLDALEPFR TAQPAQTPEP
LAYLRHAGEH GFDIALEVTL RPDGAADATT ICRTNFRHMY WSMAQQLAHH TVAGCNTRVG
DLMGSGTISG PTKDSFGSLL ELTWNGKEPV ALKGGGSRAF LEDGDELTLA GWCQGDGYRV
GFGTCVGKIL PAPGA
//