ID A0A067BW79_SAPPC Unreviewed; 792 AA.
AC A0A067BW79;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPRG_15856 {ECO:0000313|EMBL:KDO18857.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO18857.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO18857.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO18857.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK583388; KDO18857.1; -; Genomic_DNA.
DR RefSeq; XP_012210440.1; XM_012355050.1.
DR AlphaFoldDB; A0A067BW79; -.
DR EnsemblProtists; KDO18857; KDO18857; SPRG_15856.
DR GeneID; 24137540; -.
DR KEGG; spar:SPRG_15856; -.
DR VEuPathDB; FungiDB:SPRG_15856; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..173
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 193..388
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 400..678
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 792 AA; 88559 MW; 5A1B520566658309 CRC64;
MAELNTSAPA PDINPSATLQ TSMSLYFVIA AIAWVVFLNL QRRLQHVYAC RNQSLETASP
VPDSMTLFGW ILPAWRTGDD DIMEFCGLDT LIFLRVLAMG RKLAAFGIFL SAMLFPVYAT
GTNPAEFPRG NRTEIDVLER ITMSNLDQGE SRLWASIVAM YAMSFYALYL FSAEYRYYIV
RRHEYLSRDD PQQYAVVIHD LPPSLRTNET LKYYMDYLFP DDVLAVSVAV ECGDLEGLVA
QRVKARNDLE HYMALSATTG ERPTYRVKDL SMKKAPMQSV DAIDYFTEQL ATLNQAVKDE
YTKILDAQHE VRDKLLVEGY EKAAFAVTQD APVANAKLVE KSIMRRSAFV TFRSLQTAQT
CQQMLQTEKI FEMEVAAAPS PEDICWENIG RTRQEKDSWR FISTVISTAI ILFWTIPTTI
VVAFSTIETL EEKYPSIKDL LTKHPWLTEF FKQLSPIGLA VMGALAPIIM TIMSKREGHP
SGALVRASTF AKLVYFQMFQ TFFVSVIAGS LVSSVTLVLK DPSLLVSLLG STIPAQSTLF
MSYLIVKTGL DLSLEILRVM PWILGFIYNT FAPKLTARER SSPFFGLVPV TIAGNFDGGG
AVADYLLGIL LVVTFCAIAP LLSYFALLYF GLAELVYRRQ VLYVYAPSPH STGAYWPQLH
SFLVGAVVLA QITFLGLMTL KVSPGPIVAA TVLPFTSVLY HVYAQQLYPR PALNLPLLSC
ARLDKARAHR AHVDISSAFV QPALDESEPL KPDYMELQTR DDLDMVEVDA AKSKMHQGEP
TDAEAKKFGF HI
//
