ID A0A067C580_SAPPC Unreviewed; 1435 AA.
AC A0A067C580;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=USP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPRG_20876 {ECO:0000313|EMBL:KDO24290.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO24290.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO24290.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO24290.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR EMBL; KK583244; KDO24290.1; -; Genomic_DNA.
DR RefSeq; XP_012205075.1; XM_012349685.1.
DR STRING; 695850.A0A067C580; -.
DR EnsemblProtists; KDO24290; KDO24290; SPRG_20876.
DR GeneID; 24141872; -.
DR KEGG; spar:SPRG_20876; -.
DR VEuPathDB; FungiDB:SPRG_20876; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00371; HMA; 3.
DR CDD; cd02257; Peptidase_C19; 1.
DR Gene3D; 3.30.70.100; -; 3.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR010666; Znf_GRF.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR NCBIfam; TIGR00003; copper ion binding protein; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 3.
DR Pfam; PF00702; Hydrolase; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00943; CUATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 3.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS51999; ZF_GRF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01343}.
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 315..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 345..363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 539..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 576..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 747..764
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 1..65
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 80..151
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 183..249
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 1027..1421
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 1225..1265
FT /note="GRF-type"
FT /evidence="ECO:0000259|PROSITE:PS51999"
FT REGION 842..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..923
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1435 AA; 153648 MW; BBBD591F4815BD42 CRC64;
MRLVVKGMRC QKNCATRIQS ALEAVPGVAS ASVSFKDKAA TVQCDASVSA VELIHAVRSL
DAGATKSFDA YMAGDDRLVR IVQLGVEGMS CQMNCAAKVQ AALSEANGVQ AATVDFEHRV
ATITIAPGSR ITETDLIAAI ESIKGKKFKA SVHDPSVTAP AIHETAAPAP VVSVVVHPAV
ETGDVTLTVV GMTCNSCANS VETALRSTDG VLSAVVNFAT ESAYVKFTKD KVGIRSLVEV
VEAIGYEASV ATGSTTAAST ENRLVEVAAW KRRLYLALFF TFPIVILMTV LDNIPQVALG
LQSPVFQLPG TSFDSFFLLV LATPVQFLAG AKFHAEAWKG LKNHTLGMSF LVSMGTNAAY
FYGLFSDLRC VYWANAELSV PDMYMTSSML ITFILLGKTM EAIAKGRTND ALRKLFELQA
KVATMLIQDA NGNVSEEVVP IELVQRGDIL KVVRGGNVPA DGVITEGEGR LDESMLTGES
KPIKKTPGDT VLGATLNVDG LFHMRVTGVG RDTALSQIVR LVEDAQTSKA PIQAYADKIA
SVFVPIVLGL SVLTFAVWFG LVSFGYVVPP DHTGGFLFAF NFAISTLVVA CPCALGLATP
TAVMVGTGVG ATHGILIKGG EPLEVAHKVN TVLFDKTGTL TNGTPSVTDV IVLSNEWTSD
ALMWLAASAE LGSEHTLGRA IVNRGKLLAK PLEQPESFTA VSGKGITVEL SNAVVHLGNL
DYMQDCGMAV PAAVPSHRRR LEEAGKTVIY MGICDSVVAL IGISDAPRAE AKQTIAHLHA
LGLDVYMVTG DNSRTAHWVA AQIGLPSHHV MAEVLPANKT AKVQELQAQG RIVAMKRWLS
PSAAHPTPTR AKTFDDDDDD AQGMDGAGAL DSPSPVRKVR PMGDRMRELD AMLYSPKGKT
RLVPTKLQMD LSPPPPPTKA SPLRRLPPKL NLDAAPSRPV MTILTTPSKR TETPLIATAP
KEPSKPSAAD PPSVTKTNAS EPINIDDDVD DEVTEKKQVA KDGFSELLLG AKRQAAAAAN
PVAKSQQGLV NLGNTCYMNA VLQALLSLQA FVTTLRDDAW VTALTKMPLP KGHWQAKAVK
DAYDFYLVFK TMIKGHVQSA HLDPSPMKAV VGKRAQVFAN NAQQDAHEFL MNVLNELEAD
MKGVKASKQS LHQYFGGNDE KAMVTPTLAP ADVEALLPTT TFFRTTVTQT LTCSSCAYRR
HVKETFRELS LDFPALAAPK PPILCKCQKP VKRLITKKDG KNKGRPFIKC NQFPQCEFFA
WDDAPPEPPA PALDVPQLLT THFQSHTVDL KCEKCADGAS VNVTATITHA PPILVLHLKR
FEISTASMTL VKRNDIVVAP TSVDLSVFQA PNAKPAPKYR LKSIVRHLGR TAGEGHYITD
VHNQATKWTR YNDALVTEVD QAAVLTGPGA ETGYLLFYVA ETSTGKGPAL LGRSG
//
