ID   A0A067CKA8_SAPPC        Unreviewed;      1218 AA.
AC   A0A067CKA8;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=BRCA2 OB1 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SPRG_07704 {ECO:0000313|EMBL:KDO26991.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO26991.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO26991.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO26991.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583220; KDO26991.1; -; Genomic_DNA.
DR   RefSeq; XP_012202372.1; XM_012346982.1.
DR   AlphaFoldDB; A0A067CKA8; -.
DR   STRING; 695850.A0A067CKA8; -.
DR   EnsemblProtists; KDO26991; KDO26991; SPRG_07704.
DR   GeneID; 24129960; -.
DR   KEGG; spar:SPRG_07704; -.
DR   VEuPathDB; FungiDB:SPRG_07704; -.
DR   OMA; SLINCNE; -.
DR   OrthoDB; 5484321at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE   4: Predicted;
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT   DOMAIN          624..692
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   DOMAIN          695..808
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
FT   REGION          1..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1218 AA;  132309 MW;  A24EC76094A1D54A CRC64;
     MLRYRRPTTA RKGLRDATND MKRPAPGGAK EDEPSKTRGF EVPMSKKRRL HADDGPSRPM
     AADQRPLHAP RDARRAKHGI EIYEDPREDA AASRPPASEN AMVTSLFQSG RGKSVLLPAK
     KIQEYENKLS KPSEEEDKVL SHDTDRAQSA DHRRSTANVV APGALVPSLF QTGSGRAVQV
     SAEKLRSYQK QLEIEATNEV VARDEPSSTR ESIEPAAPTI LSLFQTGRGQ HVQVSADLTA
     KYRASFEAAV ADASDDPVEA LPPMKRPVAA PSSSGAVTSL FSTAAGASVK ISAAKVQQYQ
     EALARDVTED DTGAGKHVHV SAAAVQRYQR QFATSLDNDA APTVAAVGSE TVANKVKAYT
     KAFEADSVSS TAHDAGAAAL AGEKALSVFS TASGRDVTVS AEKTKAYERL FDADAPAASD
     VMVLKEAHDE TPSLFATGSG QKVDVSREKV RAYEAKLQRG DATLVALPTE DAAPPRRRAG
     SDEMPTTKPN PQRRVTFAPG DMPRTTENPV PRSAAAKPAM PSTNNGRRAF QPPRRKSMPA
     PSVVAVEPGV PKPKPKEIVV QTKSKYKAPK LTTVSFRDLH PSSSPAVSVC VDAIAASNAL
     LVHFGPNGDP TLVPSFGASS VHLLYATMVS NQFIQPALGA TLPWFLNHFR WIVWKCASME
     RTFGADLAGK YLTLDQVTFQ LTRRFQRELE QSHRSVLKKI YQRDAHSGNA MVLLVVATYP
     THWVLSDGWY ATFALPDEYL LGHGNKSLVG AKVIVWNASL INCNEGIDPL ESPIHQSFEM
     AFDPKTHVHL SINVNSTRRV HWRLPLGLED RRKHQLLQSL PLGSLKQRGG LVRSLRAVVM
     RSSGLLYLQP KDATGPRVLT EKMMEKFPQA FETAVPFLRL KVACSHPSHS VSRHATLSVW
     RPSEDVQIVC KEGAEVFVTS VAVTWSAEKK DAELNLSTVG YAPRTCMSIA DIGPTYIGDA
     DVCVYVIRLS EDKSHAFVTD TSLKLLSIRL PAAPTKAALK MWQKGSIVCV RNLLVSHYDE
     GLGLLDSVLT DTAEATTQPS KTSYFATTFE QLKLSIANGA NQTLIHALDA YILSSILHTV
     ATQETVMTQD DTGLDVDTTD NVQVEAIEAH DMTIEGHPMH VEELPDSKDF GAVVSVDVGT
     QLYDVYLPRT VCDQATDLFA PNIGLLLLRL NVKVETDDAS SNSCRRWEVA RATKLVAVSA
     SIDSPTDRIR ALLAALQS
//