ID   A0A067CZK6_SAPPC        Unreviewed;      1170 AA.
AC   A0A067CZK6;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN   ORFNames=SPRG_03419 {ECO:0000313|EMBL:KDO32202.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO32202.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO32202.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO32202.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583196; KDO32202.1; -; Genomic_DNA.
DR   RefSeq; XP_012197382.1; XM_012341992.1.
DR   AlphaFoldDB; A0A067CZK6; -.
DR   EnsemblProtists; KDO32202; KDO32202; SPRG_03419.
DR   GeneID; 24125928; -.
DR   KEGG; spar:SPRG_03419; -.
DR   VEuPathDB; FungiDB:SPRG_03419; -.
DR   OMA; EMEGFVY; -.
DR   OrthoDB; 72069at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR   GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR   GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR034085; TOG.
DR   InterPro; IPR048491; XMAP215_CLASP_TOG.
DR   PANTHER; PTHR21567; CLASP; 1.
DR   Pfam; PF12348; CLASP_N; 1.
DR   Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR   SMART; SM01349; TOG; 2.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          683..934
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   DOMAIN          940..1169
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          1110..1147
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          470..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1170 AA;  127456 MW;  BC32B6B28F2FD809 CRC64;
     MDSVDTLVYQ MEDDEPSVKL EAIRRLRELA ATLQLRPAPF PVRNARRFLN CVRRRLHDAE
     PRIVAEALQF VCDLVPVIGA ENLVHLYQIV LPPMLPMLPA DPEWDDEAAF PHSALHVLWV
     YAQHTSSLQS VMDLLMNQGL NHEDGAVREG AIGALKALLQ RNATTTLPGD VSWAMVLEVL
     IPAMEDDEER CVVAAEDAVA WLQAHVGQKQ FQRLLQTLSS RDRAILAQHA DYIQQFIGSS
     SPALGAASDD QLQFGLVPKW IVEALRNPSE APPTAMDLLG RTLSPLSSGE LLSVRSEWLH
     LFGFLAHLCA QLSSVRDRAL TLLEGLCRTM GTYLAEVVSV LAPMLATVLA ETAEPGARRE
     LVHIVLSACP VAAFLKTLVP ALQHGSCKVR EAALHLWTIA TLRQPRDAPI VRAAAFDLAA
     VLAHVCAVPI MQLLMANADA QADGLDTGQL QRRLVQRDVP FLEASGPRLL GRGDLENKTK
     LWLPDAKTPP PTVPPRQPKA EVSPQQSAEH IAKSLTVLKQ RCLNKKRGTT PPDGLRPPER
     NQKAGTPVAH SPTEDRDQRA VRTVFDEDRP IKPMRATVFE NDDAVAEAPL RARKPISLAT
     AKRVHAKEAS VLPPAAIVVE PEPETPAEGP TKPKVMTLAT RKRLEAKQKQ DDAALAPAPV
     SARSAKLKTG DDLKLALRAG KQEYVATAEL DAYPLGKSDM APCLGRLQSA EWENQFEGLT
     DLRRLCVHVP DVVASAGFSS VLKLVCTHIG NLRSAVAKNG MLAVETLCLY LGKRMDSDLD
     DVMPLLLKRA ADTNVFLSES GAQTLDAVVR GCSAPRVLSA VLPHVASKNH IIRKQVGIML
     GKLLSDGRLD VARDVDRVVM ATCSLVNDSN NEVRDVAKPT LLELRHLGAL DAARLRKLCP
     ASCVARVEQV LSSAPALKDQ VAKPLVRARS EVKDTTKYKP MAVADFDKIP TLNKQLESSN
     WKERFDALEE VQALVLKHAQ GLCQSGKVLQ VFDGLNKRLD DGNAKVNVFA LETLQTIIPA
     LGNGLDAVLS NLVPILTRSL AANNQKVAQL ADGALDLLCA HVDAKLVVPH FVSVTKVGNA
     RVKPGMLLKL DRLTQDAGLL TTQSAIHRHV LPLALDLIKE SKTDVRDANY QLLRSLYKAL
     GPSMLDSVYK LPKPHQAKLS QIIGVHITTA
//