ID   A0A067GHL4_CITSI        Unreviewed;       445 AA.
AC   A0A067GHL4;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN   ORFNames=CISIN_1g010325mg {ECO:0000313|EMBL:KDO74826.1};
OS   Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX   NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO74826.1, ECO:0000313|Proteomes:UP000027120};
RN   [1] {ECO:0000313|EMBL:KDO74826.1, ECO:0000313|Proteomes:UP000027120}
RP   NUCLEOTIDE SEQUENCE.
RG   International Citrus Genome Consortium;
RA   Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA   Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA   Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KK784883; KDO74826.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A067GHL4; -.
DR   Proteomes; UP000027120; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 2.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF97; METAL TRANSPORTER CNNM-5; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        33..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        120..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..213
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   REGION          379..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..399
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  48596 MW;  74206C9F051BAA5D CRC64;
     MQLLNAVMAT RMLTSTMKNG GGPSSEGIPF GSVWWFVYAG ISCVLVLFAG IMSGLTLGLM
     SLGLVELEIL QRSGTPSEKK QAAAIFPVVQ KQHQLLVTLL LCNAASMEAL PIYLDKLFNQ
     YVAIILSVTF VLFFGEVIPQ AICTRYGLAV GANFVWLVRI LMIICYPIAY PIGKILDWVL
     GHNEALFRRA QLKALVTIHS QEAGKGGELT HDETTIISGA LDLTEKTAEE AMTPIESTFS
     LDVNSKLDWE AMGKILARGH SRVPVYSGNP KNIIGLLLVK SLLTVRPETE TPVSAVSIRR
     IPRVPSDMPL YDILNEFQKG SSHMAAVVKA KGKSKTLPPM TDGKKPKLNE AKGGDCDLTA
     PLLSKQDEKT ESVVVDVDRP LSSGSMNRLS SSQRSDSTTN GLIYASEDIE DGEVIGIITL
     EDVFEELLQE EIVDETDEYV DVHKR
//