ID A0A067K510_JATCU Unreviewed; 1799 AA.
AC A0A067K510;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=JCGZ_18062 {ECO:0000313|EMBL:KDP26904.1};
OS Jatropha curcas (Barbados nut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae;
OC Jatropha.
OX NCBI_TaxID=180498 {ECO:0000313|EMBL:KDP26904.1, ECO:0000313|Proteomes:UP000027138};
RN [1] {ECO:0000313|EMBL:KDP26904.1, ECO:0000313|Proteomes:UP000027138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. GZQX0401 {ECO:0000313|Proteomes:UP000027138};
RC TISSUE=Young leaves {ECO:0000313|EMBL:KDP26904.1};
RX PubMed=24837971; DOI=10.1371/journal.pone.0097878;
RA Zhang L., Zhang C., Wu P., Chen Y., Li M., Jiang H., Wu G.;
RT "Global Analysis of Gene Expression Profiles in Physic Nut (Jatropha curcas
RT L.) Seedlings Exposed to Salt Stress.";
RL PLoS ONE 9:E97878-E97878(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; KK914893; KDP26904.1; -; Genomic_DNA.
DR STRING; 180498.A0A067K510; -.
DR Proteomes; UP000027138; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 2.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF07725; LRR_3; 2.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000027138}.
FT DOMAIN 10..176
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1799 AA; 206897 MW; 35B3892B4FA09B29 CRC64;
MASAAAAQEW RYDVFLSFRG ADTRKNFTSH LYKDLTGKGV VTFKDDRELP KGESVPQQLP
KAIQDSGILV VIFSQNYANS TWCLDELVKI FECKKAGRQT VLPIFYDVSP HDVRKQDGKF
GEPFTEYEKL FKNNFQKVQE WRGALTEVAN LSGWHLGDRD ESEFIQDIVE AILRRFRRSS
HSIAKDFVGM ESRLEKMYDS LDLEQLNKVR IIGICGMGGI GKTTIAGVVY KDIRWQFEGS
CFLGSVRESF EKNGIVFLQK QLLSATLMYD GIPVYDVYGG TDEIRNRFCR KRILVILDDV
DHLEQLESLI GRRDENWFGI GSRVIITTRD EHLLKQYGVD ETYCVEGLNY EDAFELFCSK
AIKNNSQEEE YRELCHEFVE YASGLPLALK VLGSSLFGQS VKEWNKTLDK LKKIPNEEIL
SKLQLSYDGL DRTSQEIFLD IACFFKGMET DYVLKVLESC GFFPDSGVGD LIDKSLITIY
YGRVWMHDLI QEMGREIVHK ESRENPGLRR RIWLDKDVSH IQVKNMEANV KAIVLHSWKQ
EEQLNAKLFS RMKELRLLIL RDVPASQDIE YLSNELRYLE WYKCPCKSFP SNFQPGKLVE
LHMKCSNIEQ LWKRSIKPVN ELLKVIDLSY SRSLIKTPDF QGLPNLEELN LEGCESLREV
HQSIGVMKRL VFLNLKNCRN LVALPSSMCN LKSLQTLILS GCSKLIKLPD RWEDMTCLEK
LDATGIGMEQ LELAEQWDFH LPPWLMSWTW KNPHPMAIVF SSGLPALKEL NASYCKLPER
AIPNDLSVSF PFLERLDLSG NNFVSLPSSI SNLSHLDSLE VSNCKRLQLL PDLPSTITSL
HANNCTSLEN LPNVSEKQNN PVNILMEFSN CSKLNDNYQG NIKAAFTWLK SHLLFLLASR
LVLSMRHERC CPEKGYYLGE PHSLMFLDIS MRFPGSEIPE WFNCQSSSNP LTLLLPPCEK
WWNIAGFVIC VVISGKAVYD CVEGLNYEDA FELFCSKAIK NNSQEEEYRE LCHEFVEYAS
GLPLALKVLG SSLFGQSVKE WNKTLDKLKK IPNEEILSKL QLSYDGLDRT SQEIFLDIAC
FFKGMETDYV LKVLESCGFF PDSGVGDLID KSLITICCGS VWMHDLIQEM GREIVHKESR
ENPGLRSRIW LDKDVSHIQV KNMEANAKAI VLRSWKQEEQ LSAKVFSRMK VLRLLILRDV
PASQDIEYLS NELRYLEWYK YPCKSFPSNF QPGKLVELHM KCSNIEQLWK RSIKPVNELL
KIIDLSYSRS LIKTPDFQGL PNLEKLNLEG CESLREVHQS IGVMKRLVFL NLKNCRNLVA
LPSSMCNLKS LQTLILSGCS KLIKLPDRWE DMTCLEKLDA TGIGMEQLEL AEQWDFHLPP
WLMSWTWKNP HPMAIVFSSG LPALKELNAS YCNLPEGAIP NDLSVSFPFL ERLDLSGNNF
KGYYLGEPHS LMFLDISMRF PGSEIPEWFN CQSSSNPLTI LLPPCEKWWN IAGFVICVVI
SGKAVYDGER PCKFILYEEN KEVWNNYLSL KFPSNDVPLT SDHLYIFSVA NPIPIKYPSY
VRFESGHCYS SPDASPIPRD PHEEQGVTKV ELTFDENVIK SCGIRIVRAN ELNELIQKRK
PSKEDTELGL KSKRERKISW YLELIDSSSA NPIPIDPCEE QSVTEDTEFG FRELRRSYLE
LIDTVIWKTT RSWERKLTSY SSDSGKYVFT EIVGYNRELG IRELNQLIDT STLTLSYSRL
HFTGLKSIFS DMGITESRDT DDIDDSIVTS ITRPWYQKLI DTVIWKKGRQ RRDVRIWYE
//
