ID A0A067NFX6_PLEOS Unreviewed; 1088 AA.
AC A0A067NFX6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=enoyl-[acyl-carrier-protein] reductase {ECO:0000256|ARBA:ARBA00038963};
DE EC=1.3.1.104 {ECO:0000256|ARBA:ARBA00038963};
GN ORFNames=PLEOSDRAFT_1093851 {ECO:0000313|EMBL:KDQ26938.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ26938.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] +
CC H(+) + NADPH; Xref=Rhea:RHEA:22564, Rhea:RHEA-COMP:9925, Rhea:RHEA-
CC COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.104;
CC Evidence={ECO:0000256|ARBA:ARBA00035831};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR EMBL; KL198009; KDQ26938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067NFX6; -.
DR STRING; 1137138.A0A067NFX6; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1093851; -.
DR HOGENOM; CLU_285117_0_0_1; -.
DR InParanoid; A0A067NFX6; -.
DR OrthoDB; 2788069at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd08290; ETR; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43981; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43981:SF2; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 408..525
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 1088 AA; 120783 MW; DEF879EE8E4DF741 CRC64;
MSEPVVVEGV PFSLQDPHIH PARGTFRRWL AALRRQFNPL PPNTVSILLR LLFPEEDKKR
KYELQETKFI PLLANCFGFS STSLEKWDAE GNSGCLGCEL RRILEETHAD PSESISSLSI
AQVDELLDEL AASSSFTDNS IRRKYLKASR RPRSAVIRCL FRPLTPLDAA CAVQIILRDM
RPLLYPQTEK HYTAALKNIN SRSYTTLTKE DVMFELDPPG SLYRMSKVVA RLDEAVEAYE
QSLKPGQPRI GIAIQIPKSS KAQSCGHGLK FLQGAKKVYA ETKYDGERAQ IHVEVPSDGT
KVRITIFSKS TRDSSLDRVG VFPIIRQALG LEEGQTPRIS QNVILDAEMV AYQNDHIDEF
WRIRGLVETT AYGVRGSCRI SGAGKPSNIA NSQCSLASSV NEGCHLALVF FDILYLDSQS
TLHRPYDERR DLLERTVQPI PHHALFSKRT LLEPRRESLT AHLCEVFADA ISNHEEGLVL
KASNSRYNDT LLPWVKVKRD YIPGLGDCLD MVILGADWEK DRGRGLYAPT GTLTTFYVGI
LENSSEIESS PGTKPAFHIY YTSSYGLDRE TLEETNFLIK NSDPVEYDKK HPPQGLPYAY
TLYPGIKPPG ILFSTPLLGE LYGDRFTKAA QSKYYELRFP RLIKIYRPKE RSWQGGVTPE
VLLSTAREIL GVDDEDKDVR DVCKGLFGQP PSPGVRSGKK RMKQQVHWVS SALRAASNRA
VVYTKNGDPT SVLTALTHPQ LPSPSPSTLN IKFLLAPINP ADINVVEGVY PAKPQLTSSL
TQSGLGSADT PVYVGGNEGL AEVTEVGSGV EGLKKGDWVI MTRPQAGTWS SNKNVSPREL
LKVPRELDGF KLDEVSGATI TVNPATAYNM IHDFTTLQEG DWLVQNGANS AVGQAVIQIA
AAKGIKTLNF VRNRDNFSEL KAQLTSLGAT TVLTYDELAD KSLRGKVKEW TDGKGIRLGL
NCVGGKDTTL MTQLLGQDGH LVTYGAMSKQ PLSLPTPMFI FKNLQAHGFW QSRWYKQRGP
AEQGELMKKL VQFMSKGQLS PPEHEIVTIA GHESDETATQ KVREIMSKLA AGRFGKKVLL
RMEEVTSD
//
