ID A0A067NLX0_PLEOS Unreviewed; 359 AA.
AC A0A067NLX0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 28-JUN-2023, entry version 27.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=PLEOSDRAFT_1038313 {ECO:0000313|EMBL:KDQ29083.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ29083.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; KL198007; KDQ29083.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067NLX0; -.
DR STRING; 1137138.A0A067NLX0; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1038313; -.
DR HOGENOM; CLU_031953_0_1_1; -.
DR InParanoid; A0A067NLX0; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF48; HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073}.
FT DOMAIN 18..355
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 359 AA; 38892 MW; 1C58A7094980EC25 CRC64;
MFRTAVRSMS ATARKSLTIG LIPADGIGRE VIPAAKQAIL ALGSDLPKTE FVELLAGFEY
FKRTGTALPE ETVEILKYDC DCALFGAVSS PSKKVVGYSS PIVALRKELD LYANIRPVIS
VRGNEKPSVD LVVVRENTEC LYIKQEELTV GPNGKEARAT RLITERASRR IGQIAFELAS
KRPRKHLTVI HKSNVLSVTD GLFRETVRAV PLLPEVNGRY NDVTVMEQLV DSAVYRLFRE
PQIFDVMVAP NLYGDIISDA AAALVGSLGL VPSINAGDDF VMGEPVHGSA PDIAGQSIAN
PLASIRSAAL MLRHLGYTKG ADRLDIAVDQ VIREGQVLTP DLGGKSKTEE VVEAVLKKI
//
