ID A0A067QKS4_ZOONE Unreviewed; 722 AA.
AC A0A067QKS4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Engulfment and cell motility protein 1 {ECO:0000313|EMBL:KDR09519.1};
GN ORFNames=L798_00862 {ECO:0000313|EMBL:KDR09519.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR09519.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR09519.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR09519.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; KK853239; KDR09519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067QKS4; -.
DR STRING; 136037.A0A067QKS4; -.
DR EnsemblMetazoa; KDR09519; KDR09519; L798_00862.
DR eggNOG; KOG2999; Eukaryota.
DR InParanoid; A0A067QKS4; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 125..270
FT /note="ELMO armadillo-like helical"
FT /evidence="ECO:0000259|Pfam:PF11841"
FT DOMAIN 374..475
FT /note="ELMO"
FT /evidence="ECO:0000259|Pfam:PF04727"
FT DOMAIN 545..671
FT /note="PH"
FT /evidence="ECO:0000259|Pfam:PF16457"
SQ SEQUENCE 722 AA; 82313 MW; D9B5EC016CDB7EFA CRC64;
MQSEFHSSVK DIVSVAVEIA NEKHLRKLNQ NEQLSEIVQA MCTEFTVSKD PGIYALQLME
QDGGNKYVTE ENRGEIKNGS ILRLVLSPSE IVKQIIVRLG PKASDTDGKL WALSKLSTLS
ADPVFAKAFL ARDGYKLITK MVLDVSESCA NIMYCLRSFT WLMHHRLVPP IQDGFVKRLI
DFVSSEKHLP VDLIECCLEI LEKAVQQKEG AMMAGIGIPD LIQHLWNMDS PSIQVKTLAF
INSLAQGPDS TKILGSMISK QMRDTIQNNI LCSHVSPTMA HELYVYQTLI LGLLQDSLTS
TIDPLGTDAK YITELNSILA STNADMQNMK GSIVSLNKER DTMTLMDKDL PDVLSKPFVN
EDFVCNHSVL ICRLTLNCML YFARRYCRTF MRMVLEEQAL SRSFPFTCEH LIQSLCELLG
VGKPLKHDGM YQPMVFTAPD DSSFMEELFC HAVLLLGTTR REMRARTPSD QEKVLCVLQR
QLREALTLQP VTLEQLDENF RRFPYTVIAE KWQLEHEKKE EWQLTHLPPI LQLKEQRSGA
ILELIEQQRI NTLLRGAKFP KYTARGQRVK KKSWFVCLST NQRAFHYGDC DDKDRLMLDC
SSKILVCNIR MLVTGKKCPH VRDVRNRKSD QYTADLAFSV ILDEEPHSLD FVAPDQRAFD
YWTDGINCLL GNHMTSATKE AEFKMLLNLE VRLQLLDTEG VFLPSKPPLV PSDPPDYNFH
YK
//
