ID A0A067QVQ0_ZOONE Unreviewed; 563 AA.
AC A0A067QVQ0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=SH2B adapter protein 2 {ECO:0000313|EMBL:KDR08566.1};
GN ORFNames=L798_01361 {ECO:0000313|EMBL:KDR08566.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR08566.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR08566.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR08566.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; KK853319; KDR08566.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067QVQ0; -.
DR STRING; 136037.A0A067QVQ0; -.
DR EnsemblMetazoa; KDR08566; KDR08566; L798_01361.
DR eggNOG; ENOG502QT43; Eukaryota.
DR InParanoid; A0A067QVQ0; -.
DR OMA; YHRMEGT; -.
DR OrthoDB; 2995825at2759; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10346; SH2_SH2B_family; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035057; SH2B1_SH2.
DR PANTHER; PTHR10872:SF2; LNK, ISOFORM D; 1.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 177..284
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 393..491
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 86..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62958 MW; AAD2470D95F0258D CRC64;
MAGVHPENEE RLNWIEFCDR HAKTAATDFA KAFCTYVSSN LPENARNTVS HRDFVRKFVD
YFVEHFEAEF TKKNLTNHKD KIVNGNNIVT SGTTNPSAPR ANSHEEFSDY SEHEADSSSP
KTLHKPFFRR LSFKGLKKGK GFFHKQHSDE LELSSHHDRY SKHDKHSKTK LAKIVVECRK
EGIVNYLMGE NIDGTQKWEK CRLALVKTVG GYMLEFYSPP KAVKPKSGVF CFLITEARET
TALEMPDHEN TFVLKAENNM EYVIEAHDTD DMRSWLATIK YCMRTMLPSQ DGSRSLPAGG
SEGDRLRGLV ERGGNKPLEA GAEVGAVGGL EHPPELPPRL QGTAVPRTAG SDTPGLRLSS
NSNFELCTSH PELEQVVTEP ELDLSTSLRE YPWFHGTLPR SDAAQLVLHE GATGHGVFLV
RQSETRKGEF VLTFNFQGKA KHLRMTLNDQ GQCRVQHLWF PTIFDMLEHF RQHPIPLESG
GTADVTLTEF VVAAIMPPTG GRGSSTGGQP TGTEARRPAA PPEPREVIIH GGTIRMRTES
MERLQERQSG LGGRAVENTY SFV
//
