ID A0A067RA04_ZOONE Unreviewed; 439 AA.
AC A0A067RA04;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=tRNA pseudouridine synthase A {ECO:0000313|EMBL:KDR20417.1};
GN ORFNames=L798_04953 {ECO:0000313|EMBL:KDR20417.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR20417.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR20417.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR20417.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; KK852605; KDR20417.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067RA04; -.
DR STRING; 136037.A0A067RA04; -.
DR EnsemblMetazoa; KDR20417; KDR20417; L798_04953.
DR eggNOG; KOG2553; Eukaryota.
DR InParanoid; A0A067RA04; -.
DR OMA; CDARTYT; -.
DR OrthoDB; 12038at2759; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 216..317
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 31..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 125
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 179
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
SQ SEQUENCE 439 AA; 49263 MW; 786183B15732AD1B CRC64;
MSGFGSRLTY SKFGFVFKLC GLFRTMCDAP PPVSKEGDSK KRPLQEDSDN TDLKKQCVEP
DRVKRRKVAL LFGYSGQGYL GMQRNPGMKT IEEDLLTALL KANFINEEAF STPQLIQFQR
AARTDKGVSA VRQVVSLKLP EDVKVETINS HLPAQIRILE IKRTTKGFNS KSSCDARTYS
YMLPTFAFAP SGVEPSESYR ITSEVMDNVR STLRGFEGTH NFHNFTSRKK PLDPSAIRYI
INFELGEPFI SKGLEFAVLK VKGQSFMLHQ IRKMVGMTIA VARGLATIDT LHKAWKTERL
DLPVAPGLGL VLEEVHYGRY NQRFGKDGIH EPLDWSETEA EAVAFKENFI YPTIIQSEIE
DKSMMSWLET LHLHSYCIRE DNLSHGLETL GEAVDMIQGI DDGDRLATLA RVAQVVQEGQ
NVMCNGNSNQ YPSEGVSSP
//
