ID A0A068RH81_9FUNG Unreviewed; 754 AA.
AC A0A068RH81;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 03-MAY-2023, entry version 29.
DE RecName: Full=Trehalase {ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=LCOR_00764.1 {ECO:0000313|EMBL:CDH49002.1};
OS Lichtheimia corymbifera JMRC:FSU:9682.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Lichtheimiaceae; Lichtheimia.
OX NCBI_TaxID=1263082 {ECO:0000313|EMBL:CDH49002.1, ECO:0000313|Proteomes:UP000027586};
RN [1] {ECO:0000313|EMBL:CDH49002.1, ECO:0000313|Proteomes:UP000027586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMRC:FSU:9682 {ECO:0000313|Proteomes:UP000027586};
RA Schwartze V.U., Winter S., Shelest E., Marcet-Houben M., Horn F.,
RA Wehner S., Hoffmann K., Riege K., Sammeth M., Nowrousian M., Valiante V.,
RA Linde J., Jacobsen I.D., Marz M., Brakhage A.A., Gabaldon T., Bocker S.,
RA Voigt K.;
RT "Gene expansion shapes genome architecture in the human pathogen
RT Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient
RT terrestrial Mucorales (Mucoromycotina).";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00001576,
CC ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDH49002.1}.
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DR EMBL; CBTN010000002; CDH49002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068RH81; -.
DR STRING; 1263082.A0A068RH81; -.
DR VEuPathDB; FungiDB:LCOR_00764.1; -.
DR OrthoDB; 1329212at2759; -.
DR Proteomes; UP000027586; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005993; P:trehalose catabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR018232; Glyco_hydro_37_CS.
DR InterPro; IPR011120; Trehalase_Ca-bd.
DR PANTHER; PTHR23403:SF6; CYTOSOLIC NEUTRAL TREHALASE-RELATED; 1.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR Pfam; PF01204; Trehalase; 1.
DR Pfam; PF07492; Trehalase_Ca-bi; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR PROSITE; PS00927; TREHALASE_1; 1.
DR PROSITE; PS00928; TREHALASE_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180};
KW Reference proteome {ECO:0000313|Proteomes:UP000027586}.
FT DOMAIN 73..102
FT /note="Neutral trehalase Ca2+ binding"
FT /evidence="ECO:0000259|Pfam:PF07492"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 86669 MW; 76F0C04617DE4170 CRC64;
MQSTIHLQST QEVDAHAPAS TYYTTGNNAG TATRRLQTLN NQRHEVDALK RRRASHDDKS
KAQKFLLDVK ETLRILVEQE DTDGDFQITV NDLGPKTFSV GTADSGGYRK IDIRGTYMLS
NLLQELALAK DFGRKHIVLD EARLNENPVS RLSRMIRCHF WDALTRRMDA HSVEIICADP
KNRSSDTHPR IYVPYHDTAA MEYYQKVADE RKHLRLIVER LPEHITPEFV KSINEKPGIL
ALAMENKDGE LQGVPFVVPG GRFNEMYGWD SYFIALGLLV DDRVELAKAM VDNFIYEIKH
YGKILNANRS YYLSRSQPPF LTDMALSVYA KTNDKEWLRR AMTAAIQEYH TVWTSEPRLD
PKTGLSRFRP DGVGIPPETE ASHFDHIIRP FAEEMQLDIN QYMQQYNDGT IKEPRLDEYF
LHDRAVRESG HDTTYRYEKR CANLATIDLN ALLYKYETDI ADCIRDIFDD EFVMPDGQVQ
HAAEWTQRAA LRKERIDKYL WNEEKGLYYD YDTVLETQST YDSVTAFWAM WAKCSSMDQA
ERMTKMSLHK FEELGGLVSG TEESRGVISL DRPNRQWDFP FGWAPHQIMA WRAFENYDMP
DIARRLAYRW LYTITKSFVD FNGVVPEKYD VVSLTHKVQV EYGNVGADFK YVSREGFGWM
NASYQIGLQL LNTQMRRALG TITNPDLFFE KALERQHLSN DAHRQRRKSS AAAAKAITQN
GGITAAITTI SGFGAFTPLT TEPPSPLPTS SFNP
//
