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Database: UniProt
Entry: A0A068XW53_HYMMI
LinkDB: A0A068XW53_HYMMI
Original site: A0A068XW53_HYMMI 
ID   A0A068XW53_HYMMI        Unreviewed;      3543 AA.
AC   A0A068XW53;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 2.
DT   25-OCT-2017, entry version 22.
DE   SubName: Full=Ryanodine receptor 44f {ECO:0000313|EMBL:CDS34291.2};
GN   ORFNames=HmN_000581500 {ECO:0000313|EMBL:CDS34291.2};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS34291.2, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS34291.2, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
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DR   EMBL; LN902919; CDS34291.2; -; Genomic_DNA.
DR   GeneDB; HmN_000581500.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   PANTHER; PTHR13715; PTHR13715; 6.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CDS34291.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2859   2878       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3061   3079       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3143   3165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3341   3364       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3424   3445       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     2625   2652       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     2653   2688       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    2631   2642       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    2666   2677       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   3543 AA;  393423 MW;  0F3D6FCC584652ED CRC64;
     MNHLGVVKPE IEDTWDFEGA IRLLQEAAAA GLKQLGSTSG SSNSNTVTSS ATLIPSTPSN
     YATTTTTSGD QTIFTSNSEQ SQSELTELLN IPTLLLPEGV GDPESGAAGP PSAVKAIWNL
     VSGSNESDKD ENLGENGASR QLALGGPESV HLRGRKLNQL ILETVCDWAR SSIIEDVELI
     RQMFFLLYRQ YGALDELRQG LTRTYAIGNR SKEDVSRLLR SLGRIRCLLG VQVGANEEVL
     LKNCLWDIMN NNVFFQHPDL IRVLAVHETV MQLMVHTLSK ASLDSPSLAA ATAAATVTAV
     NSTTSDLQHQ RAVSPNAEGN HRRGQGSTGG SILPAVVEEG EEATLNDFFA VRVYVGQGPP
     RGVGSNMGRN VTVGPTEMVV QCCRFLCYFC RTSWQNQKAM FDHLSYMLEN SSMLLARPSL
     RGICPLDVAY SSLMDNNELA LALREKQLEK VAVYLSRCGV QSNAELLTKG YPDIGWDPVE
     GERFLDFLRF TVWVNGESVE ENANLVVRLL IRRPECLGPA LRGGTKTHSS RRQRLNSQTV
     GQSGSGGAAG TTQEGLDQLS PPGSPEITGG SGGVNSAGST AGGVVDDAHS TTASQANVSS
     SSAGGGLLKG IKEGIIMSAQ IKLVKMAMDA EAQGLNPEDE DMGWRTVLMD YEDCNLFAPL
     PYNFSTLPPE EDEDYVDLGA AILTFYSVLV DLLGRCAPEL DASKSESVRG RAILQSLVSM
     QDLEGVLSLR FILPPPKLEM QLNAEGLEQW VDKSPMPPGL LPEHKAAVVL FMERVYGLSD
     PDTFVRLLEN AFLPDMRAVT LLDSAQRGVT ASDMTLALNR YICGSVLPLL TRYAHFLAVN
     EVTAGLLEST LHTAYRLATC RSITNNQRDV VSGFLVALVE HIQPFSMTSL IRKIAKNMRT
     VGRESVVSLR VLTTFYQRFG AYYSSEGWTA EYASSGPDIS GVAGGVASTG AASKPTSGQS
     AGASSTAKDL SDTSFVRPTA AGTTATATEE ERNLTAELFS LIFNNLSCRR YDAELYVYAL
     PCLTAIGCAL PPDYCSSHWD AQSRIGENDL IGADVSVHPG GPDSVVDLRA ANQQHESFRP
     MPLVTSTIKL PAALSILVDQ FAKHCHDTWA QELVDQGYVY GMTLDETRRT HPNIRPYHSL
     SQRDQMRYIQ PVTETLRAML ALGWTIDPSG VCHEDDGAGL EYRRRQFGHN PAESPQTYIP
     APKDLHGVNV TRELIDLAER LADNAHQIWA KQKLEELEEI GGGVHQLLVP YDILTDRERK
     RYRRLTHELI RYLQYWGYRL SCKPTNQQQD NTTTPGSPST ANAASSNATK QLVGERGEGH
     PSSRFAYGLL SKLLDYVEGA MSTVREDKPS RMFSRYQNLT QTSEDMKLLV KVVLPLLERY
     FYTRKSYFID PYSGASIEEK KMATMLFTKL FTLLRLKTKC FGADVNVTVS CLKCLIECLD
     IKAIVKISYA EDFVRVRLMP FFAFCADDLN LLIRNLNSGR YSHTKGTIRR GACSIDYVHM
     ILLPTLKTMF EHISKTGVGE DLLLGHLQVT SYRILNALYV LGTTSRKHAN RYELMEELNR
     HRPMLGKCLA ALTTCFPVAF LEPELSSHNP RSIAYNTEEA DYSFEARDLL QKIGKTLPFL
     HEIIDDIVRL AESGSNCVDE PHLIEVTLPM LCSYLPVWWR KNLAQRRYAH RHPGSKAASF
     FPDNEEFLAA LDAIEGDELD TIAGTGGAEV EGGEGGGEND DDDEEKGWGA ATGPITTVTA
     DLMNTVLGSV LHLIQNNIDN CNATWMTRIA TRTQPIVGNA TVDMLGKYFL PVSERLLEQA
     FAVQHMERRL GNEGEKGRDL TAACELLVRN MFALYPLLIT FVDRYRTEWL KQPTMETDRL
     FNAVANLFLI WNGSPTFKRE EETFVGIHEL DTLALIMPSS ERGTFSTDMG PRSHAGKSVG
     RGQKKGFTSL MVASIKRLLP IGLCVLGGRQ QELVQRAKRM FLKHEVEADI ADYLRYALDK
     DDDSEAKVYR WQKLLYQKID KTIALTDCHA ALNIPTKEEV INRIMTLAKV MHALYLVGHV
     APTTLNLGAW KKLVSTQRKR AVMACFRMQP FYALPRHRAI NFFLMAYHDG WLSYEQSLGV
     QLIEEITGAP FEENAILNAS TIASVAPIAG MLPSSPSDNA AGGSSDGSGG QGEAGSVCAS
     GETEAIASIA RAIMEASMYS ESSDEDNVSQ VGAEGTIAST SAISAATSAL SNEQAGGSKC
     VTGHADGSGR PVFATDYCAT PDPLRQLLTA LCRTAMDQAP DDPLYLAFAQ IMAKSCSGTD
     DDDENGGNGG GGNGEDKNEE DEEEEGPSSQ EQEEQKQRLL FEQNRLAERG AAEMVLLQLA
     ASKGEATPVA MASVELGIAI LLEGNVAVQN RMLAYLAEKR LTGFFTSLAG LMQNCSVLDL
     DTFERCRKAE GLAVGLSDME GITNLYDADF TCKIFRLLQL MCEGHNSAFQ DYLRTQSSNT
     TSVNLIICTV DYLLRLQESI MDFYWHFSNK PVIDESGRTN FIKAIKIGKQ LFRTLTEYIQ
     GPCQGNQHAL ANSRLWDAIS GFFYLFAHMQ DKLSKDPEQL DLLHEFLNLQ TEMMIMLLSM
     LEGNVVNGSI GRQMVDTLAE SSANVELTLT FFDIFLRMKE ISNSDAFLAF DVNRDGWISH
     REFRTALEQQ KSLTEDEINY IMGCVDANSD GKIDFQEFTE RFYNPARDIG FNVALLLTNL
     SEHIPGDPRL ERLLQKAKGM LEMFDPLLGR IEITNKEGRI ERVYFEVRQE NIDQWEKPQI
     KESKRTFLHS VVGESGDKEK LECFVNFAED TIFEMQHAQG ISGDDENLQI SRVVAVRNLL
     EATRLTSFFA FLGTVVSFLS PHHLWVCWAK LRQMSVVDVI ADILGLIIGL MIGAVRLVKG
     ALKISCRFIV AMTSDPTAQP PLAQQSISRW QNAGGTGGIS NFTRFGGGKI DNNLTADGNI
     KPPDITVTNQ EAQKPTDLAS ILQEKECWLL SEEEQLLLER VDCSKVEDLT RSSTRKPAVA
     GGSRLNADGG KREIGTSDGK KKQSTRSSNN EECFTAVEQK PIPTSTFLIS IFARNFYRFK
     LCALILAFII NFLLLFYKIE KRPVGGEEDV EESGFGTAFV TSISDTVSNI ADSLQNSEAD
     IGFEGEEEEF ITLADSDSYL GPLLKFLAIA HSMLSFSMLV AYYFLKVPLV IFKREKEISR
     MLEFEGIWIA EQPPDDGLRA QWDKLVLSTP SFPHMYWDKF VKKKVLKKYR EQYDQKQIIR
     LLGMKPGSTN NGPSPLKDRL EETTGNWFYP TWLQEMDLQY LLWKWGVIFT DNSFLYLVVY
     FIVSLLGNMN YFFFSCHLLD VAISFKTLAT IVQSVTHNGK QLVLTVMLTS VVIYLYTVIA
     FNFFRKFYAK EEDGEKEYKC NDMLTCFIFH LHSGLRAGGG IGDEIEPPDG DVHEALRILF
     DMTFFFFVII ILLAIIQGLI IDAFGDLRDQ LEQVREDLES KCFICGIGKE YFDATPHGFD
     RHVEREHNFA NYMYFLMHII NKPDTEFTGQ ETYVWELYQQ RCLDFFPIGN CFRKQYEEEL
     QAK
//
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