ID A0A068Y4A3_ECHMU Unreviewed; 759 AA.
AC A0A068Y4A3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=EmuJ_000527100 {ECO:0000313|EMBL:CDS37977.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS37977.1};
RN [1] {ECO:0000313|EMBL:CDS37977.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS37977.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; LN902847; CDS37977.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y4A3; -.
DR STRING; 6211.A0A068Y4A3; -.
DR eggNOG; KOG1217; Eukaryota.
DR OMA; INFRCEC; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..759
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009741514"
FT TRANSMEM 600..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..240
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 276..311
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 313..355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 357..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 392..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..559
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 740..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 197..206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 210..222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 231..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 301..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 345..354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 380..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 473..482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 511..520
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 549..558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 759 AA; 83467 MW; 58D1FB2AAC9DD48E CRC64;
MTRLGLREIS SVLRLVLLLL LVTVPHPAES NAVNPKIRNL FEFHVADLKL PSQGSMNLSS
CCLPGTWIPP DLCSAQCRIL LEVNLQPAGK MPNATVTSTT TTAKASVFRT GVVFTNGKLY
NSTLDFCINL YAKMEGPLQL HILLFHLSPV EDAILLTRLQ PLLIKGRPRN VWTTQTLQSA
AEPNPHIRLT LSYRFACPPD YYGEACERYC APRDSLLGHY KCDPKDGRIV CLPGWRGSQC
NEALCKNGCL HGTCDSPGVC KCREGWEGEA CNHCIPFPGC GHGACKFNWT LGQHEPFTCE
CQPGWSGMLC TVDTQFCSNH PNTCLNDGVC HNTPTETSPG YACQCPLGYE GYHCETSNQD
CRVHRCSGHG ICQTNGNCAC FDGFYGSNCQ FDQTECWQNP CQGNNSVCIP VKNTSESDLQ
STKVAINFRC ECQPGLSGMN CERKIRRCDA RPCLHGGKCV ELAQDSDGYQ CVCLSGYRGR
HCELNDSVCQ HLPCANGGQC VDRAHHVECR CPPGWTGPTC RQNVNECTTP ICKNGAACRD
RPGTYECLCT PGWTGRNCNV PVYNATIVTL SSSPPPPSSP TCTSACDEED NEIIWPNTFV
IIRCAVVASI IVLVSLLIFT SLLFLRRRKI WWHKKSLFEE LQRPVPPTQP GSVYWNSSAM
PEPLLICTSG DTLTRHKTLF SEAPKTLAPR KERLCAGKPL IYDLAAPSPM LTSQHIVPLC
GPSVHHHAIV YACQTPPPPP YEDLVQGKVE TGKKDSSQS
//
