ID A0A068YBE0_ECHMU Unreviewed; 1721 AA.
AC A0A068YBE0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:CDS40580.1};
GN ORFNames=EmuJ_000817500 {ECO:0000313|EMBL:CDS40580.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS40580.1};
RN [1] {ECO:0000313|EMBL:CDS40580.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS40580.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902841; CDS40580.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YBE0; -.
DR eggNOG; KOG4751; Eukaryota.
DR OMA; CVALMHY; -.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE 4: Predicted;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}.
FT DOMAIN 698..773
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 816..946
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT REGION 1417..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1642..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1694..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1643..1671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1721 AA; 189330 MW; FCC6A8AE573E58FA CRC64;
MYPKSGNYEG KSNKVLQLND KASAPCSQAF NDNFDGINLT QMLENTAVDA TLDEAPQKSV
QSFPNSPLIH ASEQCDPLLK NSLHEDACSN LSRGFKTASG GVLSAPSRQS LMRARELFKE
CMNQLDESGS NRVFHEDDPS CDKNGSPFHV LKQGDPIPKT GLCKDTSSDF GCDFKTAAGA
SLKAPSNESL SRAKRLLEEC TNQAEDSSAD HDDLFSFRKS CHGFKTASGT ALEMPSCESL
SRAKRIFEEC VEQTKDLGAC SDFDKTPKER TLWSHSKSYV SSLCRHDLID YDRPLRTHPK
TVKSGELLFE NYMKYTVDGK HGHQRENDSC GKSLSFGDFA TSDVSKSNFS INSLNLNDCQ
VAHSLHSKTA NDSPSRVGFV TDLGKLLILT SDESMKRAKR LLEDCSKDYD GSKLTDNDAQ
SDVLTHRGGK SPYVGLSKDF SEKTNKSDEC IVNKNEVEID RANGGSSVTS DTSFLVSNHE
NTSGGFASAV GRLLTPISDV TPRQATTTFS KCALNLESEL NLTNTELQSL RGDVSPMFVP
ATTGVDGEMS PTLDFDGSFE ISSQMMNVIE GTSPQFSDNV ESSEVERQRV EARMVQEAEA
DRYFKPPVKS HLNSSCRKPR TGGSLSIYSA THKIVHEPAM PGTLWRLRRC TGCSVNEDLL
SIRTSYSPEK DLHFAGDFLR LDETSSLSVN SALNLKFKLD SNIVNISYRL GDNVEVIPDS
FGYAGCAEVV RAFVCSPGVT GGLVSRRWIT HHYSQIAWRF GCVALMHYRN LVDNVFPHLS
LPDPTIQRTD GRLLLHTLLL ELKYRYDREL EAVERPPVRK IIERDDTPAK RIVLCVSHLE
KLPNHRYRGR LTDGWYHIDW VPDCMLTRVI ERGRIKVGTK LVTAGAELIQ TPSGFDGSLN
SSGDSCDNRN KGEDAHLFDN TSNGLSLRLN GNSTRPASAN ARLGFVSHPP IAHLPPIPLS
TISSEGGIVS CICVLIQRRF QLQYMETCSL HVDSNEGERT RRHHVFRDPR SEQAAERLHA
EKCHLAFDQA VNEFNSSRGS RGRRVQPQTS FLASLGLDGE ALWNAVKNAL DPDLAESDLS
AAQLDAMFRY KEAVVQEIFA QSSSKREVTQ LLRLQVAGIH PLDIEKQTEL PLTLWNPTEE
MLDILKEGSV IQLTRLQVST TRPTDPFASL ASCTTNVGQV LSLSGGRATT IRPLKAAEVI
KFSKRGQPTT STSVQDLIDR VYRPRSFLSV GSLKNIEATS FDRPRVVDFT ALVIGTKNIS
ASNSSRLHHT GEKSKLSVVY LASLRSEDGE EDFSTLAVLR IWGGLERYSL TSVLAARSRV
RFTDVQMRDH GKLSVHSDFP PGDNSEVYYI LLNYSAASYV TSEKLPRDPT IRRFQTPWKE
TPQFYSYMET CMESHFRKFF SGKSSSSLAI PNSLTSTHCS SPSTSILQQT PKPEPISVST
PCSLPNRLKG GCSHSSSPTK LETANKIAES PPMFPALKTR TRTGLCRPRR ALPIATMTPT
PTSFIGCNVS PSLGCFQLTS SRESVPSSCS PPERSLRPSH STPLPVKRSC SLIENPETHS
ELLKTSTISS SPYRHPSAKR SRSSLFSSSS PKQETGLLPQ LGSPQSPQFD FPISPPCLGS
NFLDSDSLIS VEVKVCDKSP SFQFHPEPSS PSQSDALNPP ASVSRTNAGS AAHLAMTSED
LASFDVSIAD LVKTRKRGRN SSSQNAAAAP KKRPLNLKGT P
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