ID A0A068YKJ8_ECHMU Unreviewed; 941 AA.
AC A0A068YKJ8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Regulator of nonsense transcripts 1 {ECO:0000313|EMBL:CDS42690.1};
GN ORFNames=EmuJ_001040700 {ECO:0000313|EMBL:CDS42690.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42690.1};
RN [1] {ECO:0000313|EMBL:CDS42690.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS42690.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN902842; CDS42690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YKJ8; -.
DR STRING; 6211.A0A068YKJ8; -.
DR eggNOG; KOG1802; Eukaryota.
DR OMA; VRSNDNQ; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 94..249
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 46..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..134
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 116..144
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 162..192
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
SQ SEQUENCE 941 AA; 105569 MW; 209D8ED365F7CEDF CRC64;
MDVFDNYCPS SQALTFFDPD EGLIGADTQG PDFDVIDFTL PTQSQTQSSH IDVKSSVDND
DSISTDPNKN VERLVENVDN LNLRALDDDA ETMVEELPEH ACAYCGISDP ASVVLCTNSK
KWFCNGRGNT SGSHIVNHLV RSRYKEVSLH KDSPLKDTIL ECYVCGSRNV FLLGFVPAKA
ESVVVLLCRH PCANQNKDMN WDPTQWQPLI QDRQFLSWLV KVPSDEEQAK ARQISAQQIN
RLEELWKENP EAEVIDLEKP GIEKEVNPVL LRYDDATHYC ETFVPLIRLE AEYDRKIKES
IKLEKVCVRW EVALNRKRVA YFRIPGANEG PELRIIHGDE LILIKSRGLE EEAMEGHVTK
IPDNFSDEVA LEMESIPEMF TNAPSYTVVF KWKGTTYDRM ITAVVNVNKN LEDYIKLRIL
GREMEDMVLK CNLPKRYSAP GLPELNHSQV YAVKTVLQRP LSLIQGPPGT GKTVTSATIV
YHLSQIHKGK VLVVAPSNTA VDQLCEKIDQ TGLKVVRVCA RSREALVSPV SRLTLHVQAQ
NVNGQTELRK LQQLKDEAGE LSKDDENRYR TLKKALEDEI LHAADVVCCT CVTAGSKRLW
MSFHSVLIDE STQATEPECL IPLIVGCRQV VLVGDHCQLG PVITCKKAAK AGLTQSLFER
LVLLGIRPIR LQVQYRMHPA LSAFPSNVFY EGSLQNGVTT EDRCKKIDFP WPNPDRPMFF
YCTTGQEEIS GNGVSYLNRT EAATVEKIVT KMLKVGVNPA TIGVITPYEG QRAYIVHYFH
QSGSLNSKLY QEVEVASVDA FQGREKDYVI LSCVRANEHQ GIGFLNDPRR LNVALTRAKF
GMIVVGNPKA LCKQPLWNHL LHFYKDQHLL VEGPLNNLTE YVLNFPKPKV PYSYKPGTHS
FNQLAATLAQ VAADSRSKLA AHQSALAQSH GAASSNFQLQ R
//
