ID A0A072PA31_9EURO Unreviewed; 199 AA.
AC A0A072PA31;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=EKC/KEOPS complex subunit CGI121 {ECO:0000256|ARBA:ARBA00016009};
DE AltName: Full=EKC/KEOPS complex subunit cgi121 {ECO:0000256|ARBA:ARBA00015316};
GN ORFNames=A1O9_06806 {ECO:0000313|EMBL:KEF56617.1};
OS Exophiala aquamarina CBS 119918.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF56617.1, ECO:0000313|Proteomes:UP000027920};
RN [1] {ECO:0000313|EMBL:KEF56617.1, ECO:0000313|Proteomes:UP000027920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF56617.1,
RC ECO:0000313|Proteomes:UP000027920};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as
CC an allosteric effector that regulates the t(6)A activity of the
CC complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC and telomere elongation. The complex is required for efficient
CC recruitment of transcriptional coactivators. CGI121 is not required for
CC tRNA modification. {ECO:0000256|ARBA:ARBA00025043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CGI121/TPRKB family.
CC {ECO:0000256|ARBA:ARBA00005546, ECO:0000256|RuleBase:RU004398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEF56617.1}.
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DR EMBL; AMGV01000005; KEF56617.1; -; Genomic_DNA.
DR RefSeq; XP_013259207.1; XM_013403753.1.
DR AlphaFoldDB; A0A072PA31; -.
DR STRING; 1182545.A0A072PA31; -.
DR GeneID; 25281721; -.
DR VEuPathDB; FungiDB:A1O9_06806; -.
DR HOGENOM; CLU_065847_1_0_1; -.
DR OrthoDB; 1437975at2759; -.
DR Proteomes; UP000027920; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2380.10; CGI121/TPRKB; 1.
DR InterPro; IPR013926; CGI121/TPRKB.
DR InterPro; IPR036504; CGI121/TPRKB_sf.
DR PANTHER; PTHR15840; CGI-121 FAMILY MEMBER; 1.
DR PANTHER; PTHR15840:SF10; EKC_KEOPS COMPLEX SUBUNIT TPRKB; 1.
DR Pfam; PF08617; CGI-121; 1.
DR SUPFAM; SSF143870; PF0523-like; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004398};
KW Reference proteome {ECO:0000313|Proteomes:UP000027920};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
SQ SEQUENCE 199 AA; 22000 MW; A57804A055ED16A8 CRC64;
MVRAIQLAHV PPELTLFVAL FRDVKNAAFL REQLLAANAD FEYAFIDATT IISTKHALAA
AFRAINDFLN ERLKSRNVHS EIVFSLSPNN NIGEAFRRFG VSETTGNLLV VKVATQAEIT
EESVTRHLSE NIDGQEVAFE DASLRTICDT SRIKKLYKIA SIPARKTDKQ VNGEAENNID
QTKNLEVQIL GAMALRGAA
//