ID A0A072TY88_MEDTR Unreviewed; 997 AA.
AC A0A072TY88;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=LRR and NB-ARC domain disease resistance protein {ECO:0000313|EMBL:KEH21833.1};
GN OrderedLocusNames=MTR_7g018850 {ECO:0000313|EMBL:KEH21833.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH21833.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH21833.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH21833.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH21833,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH21833.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH21833.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH21833,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH21833}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH21833};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001223; KEH21833.1; -; Genomic_DNA.
DR RefSeq; XP_013447748.1; XM_013592294.1.
DR AlphaFoldDB; A0A072TY88; -.
DR EnsemblPlants; KEH21833; KEH21833; MTR_7g018850.
DR Gramene; KEH21833; KEH21833; MTR_7g018850.
DR HOGENOM; CLU_000427_2_2_1; -.
DR Proteomes; UP000002051; Chromosome 7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR33463:SF211; AND NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR33463; NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 213..452
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 116..178
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 997 AA; 113727 MW; 254D8B9CD3D1C80C CRC64;
MGRKKNEDCR KHVTEGVENG HNYWICNYCN EKYSGGASRI EAQLGLNGKG GGIKPCSKYH
EGVYNNMAST SSNPPLQVVE GVPQVIGTHI RSLLNHQNNA EIMNLSEGMN SSGCNISVYE
SEINQLKQLV IDLERDENDI AKQLQSLESR GKKRKPEVDE WLEELLNLKE SANEMNSSDD
IHEINHFIDN MKRHKKKKPF TLSTEFVGGR LDEKIHKVLK QLDDDKVFVI GIYGMGGVGK
TLHATLVENE VKRKATFKHV FWVTVSHNYS ILKLQHNIAK RIGLKLDEDD EKVRADNLSL
ALEKKGKSIL ILDDVWKYID LKKVGIHPKV NGIKVILTTR LKHVCHQMDC QPCAILQIDP
LNGNNKDWEL FMLKLGHDGT PKIFPNEIEK IARCIVERFK GLPLAINVMA RTMKGVDDFH
QWKHALNKLR KLEMGQEVEE EIFKVLKRSF DNLMEKNLQN CFLYCALLST GTLIEKDELI
MKLVDNGQIN GSMCLEEIFV EGNTILNKLE SHSLISLYNN KVATHQMVRN MACYILKQSK
RDAIVKFKEC VTEIPLSHEW AAKLELVHMW GCDIGPIPEG MSPNCPNLST LIINRVSISH
VPESFFKYMN SLSILDISYN KRLESLPNSV SELRSLITLV LKSCYSLKHV PPLGELQALS
RLVISKTSIE EAPQGLEKLI NLKWLDLSSN KCLNMDTRSF LSNLTKIQYL NLQHTNALIK
VEDIQRMNML ECLGGGFDCK DHKQYMQKNL DMSFGPKSYI LTFASVWGED GVSLIRFDSD
DPETKTMKFG NCDHSSHILP KDLTYLCIEK NSHWVCLCDA LLCNTDFSSL RKIKTYYCQR
LKSLFCLSGF CSFCTMIHNL EVLDLQRLES LTIVCKEVFG VRQSLTQGGI FSCLKKFNIY
HCHLIEKLFR PQLVQQLQNL ETIDVQHCYS MKEIFVVSNS DDNDQSIISL PKLTRLTLYY
LPELKIVCKG SISCGSSPKV DIFNCPNLER YPTIQRC
//
