ID A0A072U6E3_MEDTR Unreviewed; 777 AA.
AC A0A072U6E3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Putative sphingosine kinase {ECO:0000313|EMBL:RHN49655.1};
DE EC=2.7.1.91 {ECO:0000313|EMBL:RHN49655.1};
DE SubName: Full=Sphingoid long-chain bases kinase-like protein {ECO:0000313|EMBL:KEH24723.1};
GN Name=25495082 {ECO:0000313|EnsemblPlants:KEH24723};
GN OrderedLocusNames=MTR_6g004070 {ECO:0000313|EMBL:KEH24723.1};
GN ORFNames=MtrunA17_Chr6g0448931 {ECO:0000313|EMBL:RHN49655.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH24723.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH24723.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH24723.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH24723,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH24723.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH24723.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH24723,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH24723}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH24723};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN49655.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN49655.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001222; KEH24723.1; -; Genomic_DNA.
DR EMBL; PSQE01000006; RHN49655.1; -; Genomic_DNA.
DR RefSeq; XP_013450696.1; XM_013595242.1.
DR AlphaFoldDB; A0A072U6E3; -.
DR STRING; 3880.A0A072U6E3; -.
DR EnsemblPlants; KEH24723; KEH24723; MTR_6g004070.
DR GeneID; 25495082; -.
DR Gramene; KEH24723; KEH24723; MTR_6g004070.
DR KEGG; mtr:25495082; -.
DR HOGENOM; CLU_015136_1_0_1; -.
DR OrthoDB; 1221222at2759; -.
DR Proteomes; UP000002051; Chromosome 6.
DR Proteomes; UP000265566; Chromosome 6.
DR ExpressionAtlas; A0A072U6E3; differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0001727; F:lipid kinase activity; IBA:GO_Central.
DR GO; GO:0008481; F:sphinganine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF113; SPHINGOID LONG-CHAIN BASES KINASE 1; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KEH24723.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RHN49655.1}.
FT DOMAIN 266..405
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 85162 MW; 14EEA2F2CA69EEE0 CRC64;
MRDMLKSGSL SRNSTGSTKS SSSASAAAAL RLSSPQQSFR RLGLCSQLST AGEHSSPIVF
PEKRSKLKAS KKNSTEAIRA SGDHQDAAAA KNFEHRIDIP GGGDEKSDLL GYVVFSGKLA
LDKRKISVNN NNKTDAQQQT SFDTTNQAAV DAKLTSKALL WGSHVLHLDD VISVSYHAGL
KHFTVHSYPM KKASCGLSCF IKPRRSRKDF RFVASTIEEA IQWVGGFADQ HCFINCLPHP
LVSSKKQASS ELFQTDTPPE LLFRCKTPPK MLVILNPRSG RGRSSKVFHR DVEPIFRLAG
FRLEVVKTTS AGHARNLAST VDISTCPDGI ICVGGDGIIN EVVNGLLSRD NQKEGISIPI
GIIPAGSDNS LVWTVLGVRD PVSAAMAIVK GGLTATDVFA VEWIQNNKIH FGLTVSYYGF
VSDVLELSEK YQKRFGPLRY FVAGFLKFLC LPRYSYEVEY LPASKPEKEG SGEREVVDMS
ELYTDIMTRS NKDGMPRASS LSSIDSIMTP SRISGGDLDT CSSTHASTEP SELVRGLDPK
SKRLSSGRSN ITAEPEVIHP QLPLSTTPNW PRTRSKSRND RGWAGLTTTH DTSKWGNAAN
DREDISSTLS DPGPIWDAEP KWDPEANWDV ENPIELPGPP DDTEVGSTKE VVPRFGEKWV
VSKGQFVGIL VCNHACRTVQ GSQVVAPKAE HDDNTLDLIM VHGNGRLRLL RFFILLQMGQ
HVSLPYVEYV KVKSVRIKSG KHTHSGCGID GEFFPLNGQV ISSLLPEQCR LIGRFRI
//
