ID A0A072UT93_MEDTR Unreviewed; 1644 AA.
AC A0A072UT93;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=NB-ARC domain disease resistance protein {ECO:0000313|EMBL:KEH29110.1};
GN OrderedLocusNames=MTR_4g025470 {ECO:0000313|EMBL:KEH29110.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH29110.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH29110.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH29110.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH29110,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH29110.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH29110.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH29110,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH29110}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH29110};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM001220; KEH29110.1; -; Genomic_DNA.
DR RefSeq; XP_013455062.1; XM_013599608.1.
DR PaxDb; 3880-AES90714; -.
DR EnsemblPlants; KEH29110; KEH29110; MTR_4g025470.
DR Gramene; KEH29110; KEH29110; MTR_4g025470.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_3_0_1; -.
DR Proteomes; UP000002051; Chromosome 4.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR33463; NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR33463:SF205; RPP4C3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 141..361
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 9..50
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1644 AA; 186148 MW; 5A045EF784063860 CRC64;
MCFFYKCNLK KLSKDLEDLE AARQRVNHSI EEAKSNGEEI ENDVLNWMKE VNQVINKVNM
LHNDPNHSKA GCYRWDFPNL IYQRQQLSRR ATKISLDVTQ KLQSGKFDCR VGYNPRHQED
IVSFSSPSPK EVLLASRRSF LNNILEALKD PSSHIIGVYG LSGVGKTYLL EEVDRFAQQL
KLFNLVVLAK TSNIENIQEV IAEGLGLKFD MQSIDARAIR LKKKMKGKEN ILIILDDICG
TLDLQKVGIP FSMTDSHTGN HNKKPTNFKL MMSSKSKENL LKMGAPENFT FRLEPLDDTE
SIDLFQFMVE DVVRDHRIKS LAPQLALKCA GLPLAITTVA RALVNKDINY WENAVRQLED
VGPEEIGALV YIPLELSYNS LECDEARTLL LLIAVLGFQK VESYLEVVMG LGVLKKIETV
RDGRHRLHVL VGYLKTSCLL RESGKCEIIE MHNMVREVAL NIASKDKHVF VKRPFSNDSM
RNCTNDSFRN CSQIILNCDI TLLPQRLDCP NLELLVLSNS KFLLEIPDNF FEGMVKLKVL
HLTKFNLCQL PSSLCCLSDL RSLSLFLCVL ENMEGIGALT NLQFLNFFGS SLISLPSQIG
ELIHLKTLDC NQTGLQEIPP NILSCLTELE ELKCRNFIIW ESNGTASEME SPDLRQLSNL
AELRQLSKLT TLELMVGTDD FPLDLQWMFK KLERFKIHFC YHLMEFYSET LNTLHICCTN
AHIEELMKRA EALFLNHSSS MALENVNQLN SDGFPLLEVL RIRFDSSLKR IVDTHLGQIF
FPNLEKLEIF GLSMLEEICR GPVAPNSFRK LTTIEVINCF KLKHLLSPSL IKELSQLVKI
HVSGCGSLEG IVFLNDNYAS VDNEIIEFVS LKTLELDHLH KLDNFCYYNS GSSEITEYQG
LEPLSSALFN SSQVAFPNLH SLTLSKLDVE NFWDDNQHIT MFNLKTLIVR DCENIKYLFL
STMVGSFKNL RQLEIKNCRS MEEIIAKEKA NSDVTALEES VMLTDMKNLK TIWHFQFDKV
ESLVVKNCES LVVVFPSSTQ KTICNLEWLQ ITDCPLLKEI FKLTPSDQSS IEDSTHLKNV
FLKTLPNVKK IWSMDPKGVL NFHDLEGLHI YQCGSLEHVL PLSVVTSCSK LNSLCISDCK
EIVAVIENED SVFIPPQFEL NALKTLSFKA LPQLKGFYGG NHTLACPSLR VMTVLGCAKL
TVFKTQESLM LLQEPLFVVE EVIPHLERLD IMIKDANLMI SQTENIGSLV TNMKHIGLYR
SENEEEEFPR ELLQSACSLE SCSFEKIFLD DRLLNEEIRL KSLKLSHLPK IYEGPHLLLE
FIGHLAVEYC PSLTNLIPSC ASFNSLISLE ITNCNGLISL ITSSMGEILG KLEVMKVKGC
NSLEAIITAE ENLDFGLLNL EVLVLESLPK LNKFSSCKSR IYLPLLVEVE VNECPLLEIF
SEGMPSTPNL LDIKRGELYY PLAGNLNDSI RSIFISEGMR RKINPGKIIT IPTTLKPLLL
LHIQKQRKLV FCPLFDQWMV FVFNRVPFTL ISFSTVLRNL ENNQMVLQDK AALQELAGDS
REPTLAVEIA LRSMADNDGA VELEELFSAN VNGVMAAAMG RPVLRLMSDM WMSHGDPHIR
GFQPLFSGGG PRRAPRLMGM CGYT
//
