ID A0A072V4A7_MEDTR Unreviewed; 1060 AA.
AC A0A072V4A7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Disease resistance protein (CC-NBS-LRR class) family protein {ECO:0000313|EMBL:KEH33000.1};
GN Name=11420356 {ECO:0000313|EnsemblPlants:KEH33000};
GN OrderedLocusNames=MTR_3g013790 {ECO:0000313|EMBL:KEH33000.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH33000.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH33000.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH33000.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH33000,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH33000.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH33000.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH33000,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH33000}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH33000};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM001219; KEH33000.1; -; Genomic_DNA.
DR RefSeq; XP_013458958.1; XM_013603504.1.
DR AlphaFoldDB; A0A072V4A7; -.
DR EnsemblPlants; KEH33000; KEH33000; MTR_3g013790.
DR Gramene; KEH33000; KEH33000; MTR_3g013790.
DR HOGENOM; CLU_000427_3_1_1; -.
DR Proteomes; UP000002051; Chromosome 3.
DR ExpressionAtlas; A0A072V4A7; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR33463:SF192; DISEASE RESISTANCE PROTEIN (CC-NBS-LRR CLASS) FAMILY PROTEIN; 1.
DR PANTHER; PTHR33463; NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 162..297
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 22..56
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1060 AA; 121232 MW; 7296A1CF448F766E CRC64;
MDLIASVASN VALPFIRQFT YVLMYNSYLI ELETEIQKLQ REEKEMRHTV EAAKRNGEEI
EDTVRDWFFR AQAAIEKAEA FLRGEDEGRV GCMDVYSKYT KSQSAKTLVD LLCEIKQEKF
DRISYRCALK CNFSPSARGY VELESRTTML NEILQVLKED SSVHMIGLYG MAGVGKTALV
KELAWKAEKD GLFDVVVMAT VTNSPDVRTI RSEIADGLGL KFDELTEVGR ASRLRQRIRQ
EIKILVILDD IWGKLSLTEV GIPFGDDQEG CKVIVTSRDL NVLTTNFGVK KVYRLEVLSE
DESWNLFEKR GENAVKDLSI QPVAMKVAKN CAGLPLLIVN LVEALKNKDL YAWKDALEQL
TNFDFDGCFY SKVHSAIELS YDSLESQELK TFFLLLGSMG NGYNKKDLLV YGWCLGLHKH
VDTLADGRNR LHKLIDNLRD ACLLLEDEKD PVVALDVVRN VAASIGSKVK PFFTVEKNAT
LKEWPRKEFL KNCHHIFLDW CLINELPERL ECPNLKILKL NSQGNHLKIH DNFFDQTKEL
KVLSLGGVNC TPSLPSSLAL LTNLQALSLY QCILEDIAIV GEITSLEILN IEKSELRVIP
PEIEHLTNLR LLDLSDCSTL EIVPRNLLSS LTSLEELYMW DSNIQWEVKV KEIESQNNTS
ILSELKNLHQ LSTLNMHIND ATIFPRDMLS FGRLESYKIL IGDGWKFSEE ESVNDKSSRV
LKLNLRMDSR ILMDYGVKML MTRAEDLYLA ELKGVKEVLY ELNDEGFSQL KHLNIKTCDE
MESIIGPTIW SVHDHAFPNL ESLIIQNMMK LERICSDPLP AEAFAKLQVI KVKNCDLMES
VFLHSMVQHL TELVEIEISE CRYMNYIIAK KIQENEGEDD KIALPKLRSL TLESLPSLVS
LSPESCNKDS ENNNDFSSQL LNDKVEFPSL ETLKLYSINV QRIWDDKLSA NSCFQNLTNL
TVDGCESLKH LFSFSVAEKL VKLQHLLISS CKLVDKIFVR EETTHHHLHI RKSHPVEMVS
ISNCFIFSFV YNFSSFSLLV VRLRVSWIDL FELVYWHKHL
//
