ID A0A074XJ05_AURPU Unreviewed; 871 AA.
AC A0A074XJ05;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:KEQ83624.1};
GN ORFNames=M438DRAFT_298963 {ECO:0000313|EMBL:KEQ83624.1};
OS Aureobasidium pullulans EXF-150.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043002 {ECO:0000313|EMBL:KEQ83624.1, ECO:0000313|Proteomes:UP000030706};
RN [1] {ECO:0000313|EMBL:KEQ83624.1, ECO:0000313|Proteomes:UP000030706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-150 {ECO:0000313|EMBL:KEQ83624.1,
RC ECO:0000313|Proteomes:UP000030706};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
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DR EMBL; KL584984; KEQ83624.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074XJ05; -.
DR STRING; 1043002.A0A074XJ05; -.
DR HOGENOM; CLU_005431_1_0_1; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000030706; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000030706}.
FT DOMAIN 389..514
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 616..858
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 61..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 96756 MW; 69D1FF9D77CA5814 CRC64;
MTGHAAVAAF FIKTMAEQQY HEQAAPTPTM AAETAAQAQL NMSASGRPRV LRTHSSPVAT
AKYAGGQQQQ SSLSRPSTPL ADAASSSLSH ARGLGIDTDE QAGSPRRLAT NGFLQTNNDS
EYEVNIAVVG SIGVGKSTFI QQSLGLANRP TAAVNARRIS VDSATYLVRM LECRLEDVHV
DKKNRITWPL DPRMPSVDAA CTLYDISNKD TFEDVPVVLN ALEKSSVPSV LVSNKCDIDK
TYRQLDPNNI EQRAKAILRS LDTLQSSISH VDSHAKGIAS LLQAVSAQRD PASSRRRTIS
SALAFSQASR SHSRQGHVRA SSAQSNTMRK DSRHDSTTMV TTPSASTNPP LDIDTNLDES
RDDITDSSRS EHASSSEDGG LDVDSQSEAP SDERGYSFDN LVDRLLGLPR SKADTRFGSV
FLALYRKFAA PGQLLEAIVH RFEALEKENC PFMTKTVSQL RYLSVIEQWI GTYPGDFAHT
KTRRRMRIFV AKLSNTRIFS AAAREMSCDL DVVTEDDDTN WACCDMDREK RGLLSPDLGW
SSRVSTLLDD PEFDFSDNLG SLSLDGGQGR NAAHSLHTDF GMLQTVDAAR RQGPSLVPVP
KIPISKMHWH MLMETPTDHI ACELTRIDWI MFSAVRPRDL VRHVSLSQTQ KAQCKSIVHV
SRMIDHFNHI RDWVANFILL REKAKHRVLM LEKLMHVARK LREMNNYNSL GAFLAGISSA
AVHRLAATRE LVSPETGKDW MKLEILMSPT RSYSAYRLAW ENSSGERIPF LPLPIRDLVA
AEEGNKTFVG DEVNGRINWR KFEVMGETVV GIQKAQGLPY RNSMLGPRND ELRALILNSN
MIRDDEALYD RSCSLESTND RRGLRDIFRR A
//
