ID   A0A074ZLG5_9TREM        Unreviewed;       684 AA.
AC   A0A074ZLG5;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Metal cation transporter, ZIP family {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=T265_13632 {ECO:0000313|EMBL:KER28168.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:KER28168.1, ECO:0000313|Proteomes:UP000054324};
RN   [1] {ECO:0000313|EMBL:KER28168.1, ECO:0000313|Proteomes:UP000054324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA   Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA   Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA   Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT   "Opisthorchis viverrini - life in the bile duct.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|ARBA:ARBA00006939}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL596705; KER28168.1; -; Genomic_DNA.
DR   RefSeq; XP_009168087.1; XM_009169823.1.
DR   AlphaFoldDB; A0A074ZLG5; -.
DR   STRING; 6198.A0A074ZLG5; -.
DR   GeneID; 20327799; -.
DR   KEGG; ovi:T265_13632; -.
DR   CTD; 20327799; -.
DR   OrthoDB; 5488029at2759; -.
DR   Proteomes; UP000054324; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003689; ZIP.
DR   PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR   PANTHER; PTHR12191:SF37; ZINC TRANSPORTER FOI; 1.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        175..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        617..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        656..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          435..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          499..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         684
FT                   /evidence="ECO:0000313|EMBL:KER28168.1"
SQ   SEQUENCE   684 AA;  74796 MW;  92EDC575F3E2A643 CRC64;
     MCRDARHHMV TRNICICFAV YAVFGMKIPC GLFCTASSTS IAEHHLTALF TSITNGTTVD
     QQQLEKFLNG LHLSSPDHAH DEEHVHNETI ETHCYSAEQM IEFFPNSQTL TKQQFGELLP
     TVVYELHTHA CHHEHSEHGH SRALDWKGVH MSTAGASSSY LTSLYPLSTL WSCPAIVGST
     VSVLVISISG LIVVALIPLM PRRFFNVISQ FLIALSVGSL TGDAFLHLIP HVVSSYHVSV
     WLFVHIGSGH GSPTSEPALT FPVAFIFHKA SNNEAVGEKD LTYPPISGAE QNGSLPMETE
     KQESTNVMQP VGLRSREHGT PNTKPSVDSA GNLTLAVNGV AYCSSRALTS LILHFRFHLY
     SIQTSHMENE LCGRPPDRPL DNARCADHLS GDVFVRVNSA SLIPGGAHHK NQQDGAVHFC
     WPSSVYIPPT ELTSSERSTA TELPTQNAVA DASELTRRQR PEASYDMVDV DNRNGQISKW
     KQNATFAESN LAKTYLDTAE EQPTHPHRDK PHGHHHGHSH DLSSVRAIAY TVIVGDGLHN
     FCDGIAIGAA FSTNVNGGLS TAIAVLCHEL PHELGDFAVL LHAGMSVKAA IFYNLLSSIL
     CAAGTVIGLL LGRIASIDTW IFMLTAGMFV YIALVDMMPE LATNRLKGQR CCHRPSILFI
     WQNVGILLGY GIMLLIAFYE TQLT
//