ID A0A075B5R5_MOUSE Unreviewed; 116 AA.
AC A0A075B5R5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 7.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Immunoglobulin heavy variable 4-1 {ECO:0000313|Ensembl:ENSMUSP00000100245.2};
DE Flags: Fragment;
GN Name=Ighv4-1 {ECO:0000313|Ensembl:ENSMUSP00000100245.2,
GN ECO:0000313|MGI:MGI:4439536};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000100245.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000100245.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100245.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000100245.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100245.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A075B5R5; -.
DR SMR; A0A075B5R5; -.
DR ProteomicsDB; 349570; -.
DR Ensembl; ENSMUST00000103464.3; ENSMUSP00000100245.2; ENSMUSG00000076655.3.
DR AGR; MGI:4439536; -.
DR MGI; MGI:4439536; Ighv4-1.
DR VEuPathDB; HostDB:ENSMUSG00000076655; -.
DR GeneTree; ENSGT01050000244871; -.
DR HOGENOM; CLU_077975_5_2_1; -.
DR InParanoid; A0A075B5R5; -.
DR OMA; MEWVGRI; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; A0A075B5R5; Protein.
DR Bgee; ENSMUSG00000076655; Expressed in spleen and 20 other cell types or tissues.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR23266:SF219; IG HEAVY CHAIN V REGION 441-RELATED; 1.
DR PANTHER; PTHR23266; IMMUNOGLOBULIN HEAVY CHAIN; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Immunoglobulin {ECO:0000256|ARBA:ARBA00043265};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A075B5R5,
KW ECO:0007829|ProteomicsDB:A0A075B5R5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..116
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008197213"
FT DOMAIN 30..116
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 116
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000100245.2"
SQ SEQUENCE 116 AA; 12874 MW; 9460FED37FDC7963 CRC64;
MDFGLIFFIV ALLKGVQCEV KLLQSGGGLV QPGGSLKLSC AASGIDFSRY WMSWVRRAPG
KGLEWIGEIN PDSSTINYAP SLKDKFIISR DNAKNTLYLQ MSKVRSEDTA LYYCAR
//
