ID A0A075B6G4_HUMAN Unreviewed; 674 AA.
AC A0A075B6G4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Crumbs cell polarity complex component 1 {ECO:0000313|Ensembl:ENSP00000356367.1};
GN Name=CRB1 {ECO:0000313|Ensembl:ENSP00000356367.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356367.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000356367.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000356367.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AL136322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A075B6G4; -.
DR SMR; A0A075B6G4; -.
DR MassIVE; A0A075B6G4; -.
DR PeptideAtlas; A0A075B6G4; -.
DR Antibodypedia; 34478; 88 antibodies from 24 providers.
DR Ensembl; ENST00000367397.1; ENSP00000356367.1; ENSG00000134376.17.
DR UCSC; uc001gub.2; human.
DR HGNC; HGNC:2343; CRB1.
DR VEuPathDB; HostDB:ENSG00000134376; -.
DR GeneTree; ENSGT00940000155152; -.
DR HOGENOM; CLU_016919_0_0_1; -.
DR OMA; NCTEFQG; -.
DR ChiTaRS; CRB1; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000134376; Expressed in ganglionic eminence and 118 other cell types or tissues.
DR ExpressionAtlas; A0A075B6G4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF1; PROTEIN CRUMBS HOMOLOG 1; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|ProteomicsDB:A0A075B6G4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..51
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 53..89
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 95..266
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 268..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 331..518
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 520..556
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 558..593
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 595..631
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 79..88
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 294..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 562..572
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 583..592
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 621..630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 674 AA; 74689 MW; 468935C5CCB4C06F CRC64;
MTSNGVALLN FYNMPSTPSF VGCLQDIKID WNHITLENIS SGSSLNVKAG CVRKDWCESQ
PCQSRGRCIN LWLSYQCDCH RPYEGPNCLR EYVAGRFGQD DSTGYVIFTL DESYGDTISL
SMFVRTLQPS GLLLALENST YQYIRVWLER GRLAMLTPNS PKLVVKFVLN DGNVHLISLK
IKPYKIELYQ SSQNLGFISA STWKIEKGDV IYIGGLPDKQ ETELNGGFFK GCIQDVRLNN
QNLEFFPNPT NNASLNPVLV NVTQGCAGDN SCKSNPCHNG GVCHSRWDDF SCSCPALTSG
KACEEVQWCG FSPCPHGAQC QPVLQGFECI ANAVFNGQSG QILFRSNGNI TRELTNITFG
FRTRDANVII LHAEKEPEFL NISIQDSRLF FQLQSGNSFY MLSLTSLQSV NDGTWHEVTL
SMTDPLSQTS RWQMEVDNET PFVTSTIATG SLNFLKDNTD IYVGDRAIDN IKGLQGCLST
IEIGGIYLSY FENVHGFINK PQEEQFLKIS TNSVVTGCLQ LNVCNSNPCL HGGNCEDIYS
SYHCSCPLGW SGKHCELNID ECFSNPCIHG NCSDRVAAYH CTCEPGYTGV NCEVDIDNCQ
SHQCANGATC ISHTNGYSCL CFGNFTGKFC RQSRLPSTVC GNEKTNLTCY NGGNCTEFQT
ELKCMCRPGF TGEW
//
