ID A0A075LRI3_9EURY Unreviewed; 349 AA.
AC A0A075LRI3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=L-threonine 3-dehydrogenase {ECO:0000313|EMBL:AIF68939.1};
DE EC=1.1.1.103 {ECO:0000313|EMBL:AIF68939.1};
GN Name=tdh {ECO:0000313|EMBL:AIF68939.1};
GN ORFNames=PAP_02555 {ECO:0000313|EMBL:AIF68939.1};
OS Palaeococcus pacificus DY20341.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Palaeococcus.
OX NCBI_TaxID=1343739 {ECO:0000313|EMBL:AIF68939.1, ECO:0000313|Proteomes:UP000027981};
RN [1] {ECO:0000313|Proteomes:UP000027981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY20341 {ECO:0000313|Proteomes:UP000027981};
RA Zeng X., Shao Z.;
RT "Complete Genome Sequence of Hyperthermophilic Palaeococcus pacificus
RT DY20341T, Isolated from a Deep-Sea Hydrothermal Sediments.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AIF68939.1, ECO:0000313|Proteomes:UP000027981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY20341 {ECO:0000313|EMBL:AIF68939.1,
RC ECO:0000313|Proteomes:UP000027981};
RX PubMed=26383653;
RA Zeng X., Jebbar M., Shao Z.;
RT "Complete Genome Sequence of Hyperthermophilic Piezophilic Archaeon
RT Palaeococcus pacificus DY20341T, Isolated from Deep-Sea Hydrothermal
RT Sediments.";
RL Genome Announc. 3:e01080-e01015(2015).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP006019; AIF68939.1; -; Genomic_DNA.
DR RefSeq; WP_048164547.1; NZ_CP006019.1.
DR AlphaFoldDB; A0A075LRI3; -.
DR STRING; 1343739.PAP_02555; -.
DR GeneID; 24841639; -.
DR KEGG; ppac:PAP_02555; -.
DR eggNOG; arCOG01459; Archaea.
DR HOGENOM; CLU_026673_11_0_2; -.
DR OrthoDB; 73567at2157; -.
DR Proteomes; UP000027981; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008743; F:L-threonine 3-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:UniProt.
DR GO; GO:0006567; P:threonine catabolic process; IEA:InterPro.
DR CDD; cd05281; TDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR004627; L-Threonine_3-DHase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR00692; tdh; 1.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43401:SF2; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AIF68939.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 16..345
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 349 AA; 37808 MW; AA3A73B4430B67B4 CRC64;
MDEKMVAIMK AKPAYGAELV EVDVPKPKEG EVLIKVLATS ICGTDLHIYE WNEWAQSRIK
TPQIMGHEVA GEVIEVGPGV DDIQVGDYIS AETHIVCGTC YQCRNGQYHV CQNTKIFGVD
MDGVFASYAI VPAQNAWKNP KEIPPEYATL QEPLGNAVDT VLAGPIAGKT VLITGAGPLG
LLGITVAKAS GASLVIVSEP SEFRRDLAKK VGADVTINPI EEDVVKEVKD LTDGNGVDVF
LEFSGAPKAL EQGLQAVTPA GRVSLLGLFP GNVSFDINNL VIFKSLEVHG ITGRHLWQTW
YTVSNLLRSG KLNLDPVITH KYKGFDNFEE AFELMRAGKT GKVVFFPKE
//
