ID   A0A075R3W5_BRELA        Unreviewed;       747 AA.
AC   A0A075R3W5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=BRLA_c029150 {ECO:0000313|EMBL:AIG27227.1};
OS   Brevibacillus laterosporus LMG 15441.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=1042163 {ECO:0000313|EMBL:AIG27227.1, ECO:0000313|Proteomes:UP000005850};
RN   [1] {ECO:0000313|EMBL:AIG27227.1, ECO:0000313|Proteomes:UP000005850}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 15441 {ECO:0000313|EMBL:AIG27227.1,
RC   ECO:0000313|Proteomes:UP000005850};
RX   PubMed=21914864; DOI=10.1128/JB.05696-11;
RA   Djukic M., Poehlein A., Thurmer A., Daniel R.;
RT   "Genome sequence of Brevibacillus laterosporus LMG 15441, a pathogen of
RT   invertebrates.";
RL   J. Bacteriol. 193:5535-5536(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP007806; AIG27227.1; -; Genomic_DNA.
DR   RefSeq; WP_003335901.1; NZ_CP007806.1.
DR   AlphaFoldDB; A0A075R3W5; -.
DR   STRING; 1042163.BRLA_c029150; -.
DR   KEGG; blr:BRLA_c029150; -.
DR   eggNOG; COG3973; Bacteria.
DR   HOGENOM; CLU_010312_4_0_9; -.
DR   Proteomes; UP000005850; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000005850}.
FT   DOMAIN          193..576
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   COILED          12..39
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         214..221
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   747 AA;  86493 MW;  902534EFD6B63A83 CRC64;
     MTIHHPAYKE EQDRLEKTVH TIEKEIGQLR EDLREATDDY VKQVVNSSKA RDLFHLESSV
     NKPYFGRVDF MKDETYEMDS VYIGKRGIVE RDTMDSVVVD WRAPIASLYY SGESKDAFYR
     TLQGIVRGEV KLKRNFAIED GQITGIYDGA LKETINREIG TPEDFLEEGY IDEFLASSLN
     QNNDSRLKDI VATIQTEQND IIRAEKDRAI VVQGVAGSGK TTIALHRLSY LIYNYQHLIA
     SKKFMVFAPN KLFLTYISDV LPELGVEDVQ QATFSEWAAK QVKVLLPKGW RIVDPSKPLL
     LFFEDDASKQ VQKRQTWNRM SFKGSVHCRN MLDKYMDYLL HELITYKDLR FIYNKTKHVF
     EMKKADIRQL FINEFAHLPY HRRIEALAKH VKQQMTQQLF THLREEKIDL DKPSLLRFEK
     KMDELLALYL GKWPEIDAFT VYTQLLQDWE LLRKLTSEDI SDEWLQDVVE TSKAIIEEER
     IEAEDLAPIL YLRHLLEGSG KEAPFDHTVI DEAQDLSYLE ILVLSLHTKN ESMTIVGDLA
     QGIHAYRGLD SWQPVLRNIF KKKTDFYTLE QSYRSTVEIM NWSNEVLQGT QLPEITEAKP
     VLRHGEEPLF LRAKNQSNML EDIKKRVEKS LALGHQTVAI VTKTIHESKK IAKALKEKGL
     ELHHLGVKDK EFPGGVTVLP AYLTKGLQFD VVIVLHVDDE HYKENVMDAK LLYVTMSRPV
     HQLLLYIQGD AKVTPWLKTK AAAIQEL
//