ID A0A075R9Z5_BRELA Unreviewed; 2239 AA.
AC A0A075R9Z5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=PKS domain-containing protein {ECO:0000313|EMBL:AIG26360.1};
GN ORFNames=BRLA_c020390 {ECO:0000313|EMBL:AIG26360.1};
OS Brevibacillus laterosporus LMG 15441.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=1042163 {ECO:0000313|EMBL:AIG26360.1, ECO:0000313|Proteomes:UP000005850};
RN [1] {ECO:0000313|EMBL:AIG26360.1, ECO:0000313|Proteomes:UP000005850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 15441 {ECO:0000313|EMBL:AIG26360.1,
RC ECO:0000313|Proteomes:UP000005850};
RX PubMed=21914864; DOI=10.1128/JB.05696-11;
RA Djukic M., Poehlein A., Thurmer A., Daniel R.;
RT "Genome sequence of Brevibacillus laterosporus LMG 15441, a pathogen of
RT invertebrates.";
RL J. Bacteriol. 193:5535-5536(2011).
CC -!- PATHWAY: Antibiotic biosynthesis; bacillaene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004789}.
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DR EMBL; CP007806; AIG26360.1; -; Genomic_DNA.
DR RefSeq; WP_003337213.1; NZ_CP007806.1.
DR STRING; 1042163.BRLA_c020390; -.
DR KEGG; blr:BRLA_c020390; -.
DR eggNOG; COG0456; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_230775_0_0_9; -.
DR Proteomes; UP000005850; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 1.10.1240.100; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS51186; GNAT; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005850};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 514..704
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 737..817
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 845..1274
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2239 AA; 253701 MW; 5FC73E3D847A7CE6 CRC64;
MLSTLHHYSH GYLAIPVLLS CKKRGLFDLL QKSRSTPFSQ LVDELHANSG HLRSALQLLE
SLQILCRDSK DTYALLPGWN VVETIPEDVM ELFNFPMKEY FKKSQRKYRL QKWIELSGKQ
WNVDNAMYSH FLDGIVMIPL LFALNEHRFI LRDSPQQNEL VLQNLSGIAK QEITQLFQQK
NWMDQTRKNG VLTETGKYML DAILNTASIH SYRSIIKNMD QLLFGDCQAL VASTNQAYET
YMERMLEMLE CGFQQEEYFC DLEQTIISVF DREPVEEQPK YIANMGCGNG LLLKKIYETI
KMKSRRGKRF DEYPLTLIGI DNKEESLAKT AITLKDINHV LFKGTLDNLN ELMIDLRKEG
IRDTEHILYV QSFFNHDRPC IISAETVEAR GQAPSFTKSI FVDQNGRECS STLGMKKLHE
QLQHWSHLVN KHGLILLEAH CLEPKTIRPY MDKYEGLHVD AIHRFSQKLL VEADTYMLTA
AEIGLFPHKQ HFHKYPKTML FSRITLHLLE QREYRIRMAN ENDISVLRQL ELQCWGEELA
APTERILHRI RKYPEGQLVL EVENRVVGVI YSQKIRDMNE IKGLQSNTVE QLHHTEGTII
QLLAINILPE MQDRKLGDQL LEFMLQRCSL ISGVRSVIGI TRCKDYQRYS TIASDKYITL
RNKNNKLVDK TLRFHEMHGA TIKELIPNYR PLDDANLGYG VLVEYDMLNR GNDEPPAIER
NQECHEQNSH SFQTGSTDRS ETITAFVLDC IGSLLNEERK DVLAYVDRPL MELGLDSGDL
LELNDQLGTR FRIELETTFF FTYNTVRKII SYLIENADEI AQASASEESV SKNEAVSWSH
SNVEKDDIAI IGAACRLPGG VSNLDELWEL LVNNRDAIRR MPEHRWAWPD KIHPATEHKG
IDQGGFLDHI AEFDPLFFRI SPSEAEILDP QQRLLMELSW ECIEGANYSA STISGSNTGV
FIGASGSDYS KLLDRYSDEV QAKYGIATSM AILSNRISYF YNFHGPSVQI DTACSSSLVA
VHQAVTSLQS GECEQALVGG VHLMCHPANS IAYYKAGMLS TDGKCKTFDK AANGYVRGEG
GVVLLLKPMK QAERDGDSIL GVIKGTATNH GGQANGITVP NPAKQAALIK KAFRSADIAP
ESVGYIEAHG TGTSLGDPIE FAALKDAFLE LSQQSDNRNE PYCGLGSIKT NIGHLEAAAG
LAGLVKVLVS LRHRMIPASL HFQELNPHIP IENSPFYLVT SNQKWMPPHR EGLRRAGISS
FGSGGSNAHI VIEEYRSNHR VDTKRATSNS NPVMIVLSAR NENRLQEQVK QLLQAIKNQN
LTDVHLKDMA YTLHVAREAM EERFATVVCD IDELEKSLLD YLDRKGTPKS NYQGNVNENH
SISSLSIGNE EKHEMVNHFI VNNDLHQLAY LWVSGLDIDW KVLYKSEADY RKMSLPTYPF
ARERYWISEI SSRYDMSQTE QISADTRDIL HPLLQQNTSN LSTIRFCSTF TGKEFFLKDH
VVSGSKVLPG VAHLEMARKA MEQALENKHD QVIELHNVIW KKPILLEEES KQVQIRVFSG
VQNEINYEIY SEEIPGSGKP VVFSSGYAVC REQKEAFVLD ISGILSACKQ HVLTGRECYQ
AFQQVGITYG KSHQGIQRVH IAEDQLLAEL VLPACIKHTQ EQYVLHPSLL DAALQASLVI
QMQVQNTYNT SVQPSLPFAL ELIEIVRPCT SKMWAHVRHS EDYISGNETQ KYDIDLCDDR
GNVCVRMFGF SSRILEGDIA TGGSIDSTQR ETIITQPFEP VMISPIWEAI RHEEAQKLPA
LTDNLVIVGG NESIWNEIRK QYPHARVLSI HHDHSVEEMV QKFSQLDPID HMLWIAPEEQ
LPSLTDDSII EGQEKGVIYL FTIIKSLLAL GYDSNQIGWT VITQKAQPLH KYDEVNPTHA
SIHGLMGTLA KEYSHWKIRV IDLESLASWP MQELFTLPSD ADGNPYVYRE QQWHQQELVP
VRYNQQEETL YKTGGVYVVI GGAGGIGEVW SEYVIRMYEA KVIWIGRREK DANIQAKIDR
LASIGPTPSY IMADATDQEE LYRAYEEIKQ QYGTIHGIVH SAIVLLDKSL ANMEEERFRA
GLRVKVDVSV NIAEVFQGEP LDFVLFFSSM NSFVKAAGQS NYVAGCTFKD AFASQLALEW
PCAVKVMNWG YWGTVGTVAS EEYQRRMKSR GVGSIEPPEA MKALEALLIG PMNQLAFAKM
TTSSTWVEVN RGKCITIYQ
//
