ID A0A076MN01_AMYME Unreviewed; 645 AA.
AC A0A076MN01;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:AIJ20381.1};
GN Name=acsA {ECO:0000313|EMBL:AIJ20381.1};
GN ORFNames=AMETH_0289 {ECO:0000313|EMBL:AIJ20381.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ20381.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ20381.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ20381.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009110; AIJ20381.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A076MN01; -.
DR STRING; 1068978.AMETH_0289; -.
DR KEGG; amq:AMETH_0289; -.
DR PATRIC; fig|1068978.7.peg.310; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_3_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000062973}.
FT DOMAIN 33..89
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 92..463
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 645 AA; 70484 MW; FDBD01E94895AFB5 CRC64;
MLWRPDPERV AASRIQAFRD WLRAERDVSL DDYDELWRFS VDRPADFWGA AAEFLGIRWH
AQPSAVLGDA RMPGAQWFPG GTLNYTEHAL TGADDDLAVI FRREDGLSAR LTYRELREQV
AAARAALVEL GVGRGDRVVA LAPNCPQTLV AFLATASLGA IWSSCSPDFG VRAISDRFAQ
IEPKVLVAIN GYVYNGRSFD VRPTVEELRE RIPSLTATVL VDYAGGGTVN SALAWDALLD
RHTGAEMAYE PVPFDHPLWV LYSSGTTGLP KGIVQGHGGI VLEHLKATML QMDLGPGEKF
FWFTTTGWMM WNFLIGGLLA RSTIVMFDGS PGHPDLNTLW RLAAEERITY FGTSAPFVQS
CLKARIRPAA SFDLSALRAL GSTGAPLSDD GFRWIADEVG RSVQICSVSG GTDLCAAFVA
AAPDVPVWLG ELSCRALGAA VTAFDEDGRE VVDEVGELVV TKPMPSMPVF FWNDEDGSRL
REAYFDMYPG VWRHGDWIRI TPRGSAVIYG RSDSTLNRGG VRMGTAEFYR IVEGFDEIAD
SLVIDTTRAG NTDGELLCFV VMAPGADLAA VEPELRAQLR RGLSPRHVPD RFIEVAEVPR
TLNGKKCEVP VKKILTGVAP ERAVSRDALA NPGALEPFVD MARGS
//
