ID A0A077DJJ4_9BURK Unreviewed; 1148 AA.
AC A0A077DJJ4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=IX83_07885 {ECO:0000313|EMBL:AIL33223.1};
OS Basilea psittacipulmonis DSM 24701.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Basilea.
OX NCBI_TaxID=1072685 {ECO:0000313|EMBL:AIL33223.1, ECO:0000313|Proteomes:UP000028945};
RN [1] {ECO:0000313|EMBL:AIL33223.1, ECO:0000313|Proteomes:UP000028945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24701 {ECO:0000313|EMBL:AIL33223.1,
RC ECO:0000313|Proteomes:UP000028945};
RX PubMed=24581117; DOI=10.1186/1471-2164-15-169;
RA Whiteson K.L., Hernandez D., Lazarevic V., Gaia N., Farinelli L.,
RA Francois P., Pilo P., Frey J., Schrenzel J.;
RT "A genomic perspective on a new bacterial genus and species from the
RT Alcaligenaceae family, Basilea psittacipulmonis.";
RL BMC Genomics 15:169-169(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP009238; AIL33223.1; -; Genomic_DNA.
DR RefSeq; WP_038500998.1; NZ_CP009238.1.
DR AlphaFoldDB; A0A077DJJ4; -.
DR STRING; 1072685.IX83_07885; -.
DR KEGG; bpsi:IX83_07885; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_009270_0_0_4; -.
DR OrthoDB; 5905204at2; -.
DR Proteomes; UP000028945; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000028945}.
FT DOMAIN 6..486
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 498..775
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1148 AA; 131916 MW; 4AA4D561DCE9E44F CRC64;
MSKDKLPSDI IAREKALNPS KSFIVQAPAG SGKTHTLTHR ILALIPTVKK PEEILAITFT
NKAASEMRSR LIKELREGQS ELAIKAREYS HAQKWDLINT PSRLNIKTID AFCAQLVRST
PFISGAGAAP TQSENFQVLY ENAIRRTLAK NKDYVIHFLN YIDNNMNSAI QLLSDMLGKR
DQWIHIVSNS DEYIADKLVL IYAEYLKSHI TFVSQALSKL DFRFLHECAQ YSIAASEYLG
NSPLAWDKLK NWDGREPKPL KQGNIDFSEY LTFIYLAHFL TTKTHAIRKT VSKKDGFPSA
KEVPPGLEDK KQTFIEYLEI LATHENIVQA LTDLKFMPTE PPSEQVLHDI AYIMDTLKDA
HEELQKEFQR TSEVDFQEIA LRAIQALSSD GETPTELLLK KDQQIQHILI DEFQDTSKSQ
MDLLNLLVSG WDGSQNRTLF LVGDPMQSIY RFRKAEVGLF LKVWQEKRIG NVFIEPLSFV
ENFRSSPTII DWVNKTFQSA FPIIDNISTG AIHFHRSVAF KEAEPTDQVD IRLYAGYQDK
GDDPEKATQE ALLDLCQTLS SKNKSTAILV RSRTHITPLL PEFQKRGIPI NCVDLLSLWD
YPEVIDIVQL IKALVQINDR IAWASLLRSP LCGLDMATLT KLLDNHHNPF ADLTIPSLLF
RTFNDPDSFL NQIPSDVRKR LLRFTHLMLR QLEEDSGLPF SSQVLNLWRA LGGDIIYPDD
NARNNIEVVL KILDSLAPYG DLDVHEFEKA VKEHHASTFA QDGAIEIMTM HKSKGLEFDH
VIVYGLDRGQ NRGDSPIVYT DTLSTGEMIV SPKKASFEEE GPGFTTLIKR NETQRNEYEK
MRLLYVACTR AKSHLHIFAS TLYNDNHEEV KQSSLWHTIS EHFKEDVQIV HINQDTEELQ
TLPNHHLMVI DDASIENSES VNQPQYTHLT KAGIDFLNEQ KYLPYEEKEL DSFWGSLNFS
STLKPRSKHY LQKQQAHFGE VFHQFMEWMA LDKMQGWDEQ RIDDSSDLIE KTLHLYKVSD
RVIKDAVSEI QKSLKAAISH PQLKEWIQTK NCMPEWSVYT QHDSQTKNRI IDLLVLDKDE
IILLDYKTDA RLENESISEF KSRLITRYKE KMAEYLDILK QYYPNMPIRS YLYATALSPE
DVLIELND
//
