ID A0A077E9R0_9FLAO Unreviewed; 1417 AA.
AC A0A077E9R0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:AIL44267.1};
GN ORFNames=BD94_0492 {ECO:0000313|EMBL:AIL44267.1};
OS Elizabethkingia anophelis NUHP1.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Elizabethkingia.
OX NCBI_TaxID=1338011 {ECO:0000313|EMBL:AIL44267.1, ECO:0000313|Proteomes:UP000028933};
RN [1] {ECO:0000313|EMBL:AIL44267.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL44267.1};
RX PubMed=24012265; DOI=10.1016/S0140-6736(13)61858-9;
RA Teo J., Tan S.Y., Tay M., Ding Y., Kjelleberg S., Givskov M., Lin R.T.,
RA Yang L.;
RT "First case of E anophelis outbreak in an intensive-care unit.";
RL Lancet 382:855-856(2013).
RN [2] {ECO:0000313|EMBL:AIL44267.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL44267.1};
RX PubMed=26019164; DOI=10.1093/gbe/evv101;
RA Li Y., Liu Y., Chew S.C., Tay M., Salido M.M., Teo J., Lauro F.M.,
RA Givskov M., Yang L.;
RT "Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen
RT Elizabethkingia anophelis in Response to Oxidative Stress.";
RL Genome Biol. Evol. 7:1676-1685(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP007547; AIL44267.1; -; Genomic_DNA.
DR STRING; 1338011.BD94_0492; -.
DR KEGG; eao:BD94_0492; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_10; -.
DR Proteomes; UP000028933; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 1180..1207
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1417 AA; 156418 MW; 28FD34EFD237048A CRC64;
MVITVSPTLA AQEVEQLVTF PVEQTMVSIP GIKDMRSFSR FGLSIVTIVF KENVDIYWGR
QQVQERLTIA EKSIPEGVGT PEMAPVTTGL GEIYQYSIHP KKGYEDKYDA TELRTIQDWI
IKRQLLGTPG VAEVSGFGGF VKQYEIAIEP DRLASQNINI SDIFTALEKN NQNTGGAYID
KGPNAYFIRS EGLVKNIEEI KKIVVKNEAG VPILLRDVAE VRFGNGPRYG AATRNGEGET
VTGVVMMLKG ANSSEVITNV KAKVAEIESS LPEGVEIEPF LDRKKLVDGA ISTVSTNLIE
GALIVIFVLI LFLGNLRGGL VVASVIPLAM LFAISMMNLF GVSGNLMSLG AIDFGIIVDG
TVIIVEAVLH RITGSKDRYG GVAKLTQEQM DEEVYQSSRK IRSAAAFGEI IILIVYLPLL
ALVGVEGKMF GPMAQTVSFA ILGAFLLSFT YVPMMSALVL SKKTTHKENF SDRMMKAIQR
VYTPIIEGAM KMKLLVVSIA VGLFIITLFV FNRMGAEFIP QLDEGDFAVE TRVPVGSSIN
QLIDVSQKAQ TILRKNYPEV EEVVNKIGSG EIPTDPMPIE AGDMIVKLKP KKEWTSAKDR
EELIEKMQAD LSVIPNATFS FQQPIQMRFN ELLTGAKQDV VLKIYGEDLD VLSDLASDVG
RKIKNVEGVE DLYVEEITGL PQISIQFNRD KIAQYGMNIE DVNSAIETGF AGKAAGLVYE
GERRFDLVVR LDNASRADIT DVQNLFVSTP TGQQIPLSEV ADISYKPGPV QIQRDNAKRR
ITLGFNVRNR DVKSIVNDIQ DIVGAKVKMP AGYHITYGGQ FKNLEEANAR LAVALPVALL
LILLLLYFTF RSVKQGLLIF TAIPLSAIGG VFALLIRDMP FSISAGVGFI ALFGVAVLNG
IVLIAEFNRL AKEGVNDIYE RVRIGTRVRL RPVLMTAAVA SLGFLPMAIS SSSGAEVQRP
LATVVIGGLI TATALTLVVL PVLYIYFTKS SFKMRKPKTL PTAILLLGFL GLPSVMNAQV
PTNSGTRVLT LQQSIDEALK NNNSIKIAEY NINVQQALKK GSVTIPKTEI SYTQGVVSNP
TINDNLINVT QRFDFPTVYS NQSKLAQERI RSSEKYKAVT ENDLVEDVKL AYLQYQYILE
KRRLLLEQDT IYSKLSKASN ARYRTGESTS LENATSSVQY RQIQNELEKN EADIQIAKRL
LQTLLNTTDD ISIADTALVV REELLAIDGV STTNNPIIQY LQQEINVSQR EISLQRSKML
PDIILGYNGQ TYKGLQTING VDRTYTGKDR FSFFQVGISI PLFPGGYKSQ INAAKINEQI
AQKQVELTTT NLNGQLKELA QQYVKFQKSL NYYQTQALPQ ADLIISNSDK SFRNGDISYT
QYLQNLTLSN NIHSEYIDNL YNLNRVIISI EAILGNN
//
