ID A0A077YX33_TRITR Unreviewed; 1614 AA.
AC A0A077YX33;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=valine--tRNA ligase {ECO:0000256|ARBA:ARBA00013169};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN ORFNames=TTRE_0000029701 {ECO:0000313|EMBL:CDW52038.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW52038.1};
RN [1] {ECO:0000313|EMBL:CDW52038.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW52038.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
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DR EMBL; HG805814; CDW52038.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077YX33; -.
DR STRING; 36087.A0A077YX33; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF111; VALINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1115..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1253..1271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1277..1303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1315..1338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1366..1390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1419..1436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1448..1474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..117
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 186..780
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 829..976
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 1614 AA; 184602 MW; 5CB6DC7D5FEF33EF CRC64;
MNCEVSYLHR ADGSCIYTQG KTTVIASVNG PGDLKNLKQC ADSAVIQVVV KRSIGGNSAA
NAQTAFILEN LCTSAVIVSL LPKTLISIVV QELESDGSFL QAAVNAVCLA LIDSGLPMFD
TFAAATVAIL PQSENIIPSP SSQVERDAEC LMTAVFLHHQ PGDLFYCWSR EAAPATYDSK
FVQNGWYDWW LRNDFFNPAP STDKHPFVMC MPPPNVTGTL HMGHALMLAI GDCIVRSHRM
CGHHVSWIPG FDHAGLATQL VVEKHLFNSE GLLRKNMSRQ DFVTACEKWS SEKMVAMRKQ
MESIGCSCNW KRCFYTLDQK FSIAVVEAFR RLHKDGLLYR DYRVVNWSPL LQSSISDAEV
DVKSIDQPTD IPVPGRTKAV SFGYLYFINY PIADSSNGQS ITIATTRPET MLADEAIAVH
PADSRYSSLV GRHVRHPLLT NRLLPVIADA QVDRDVGTGA VKVTPSHSRA DFEIARAHGL
SLEKRCIDAS GHIISPELPE LDGLNRFECR EKIVRWLIDR DLLMDCRSHV TNVPMCRRTG
DILEPVPKEQ WFLRCDSMAE RTMALLPRIH ILPEGMRNEW KNWLSHRVDW CLSRQSWWGH
RIPAYRQKLD LVSSLLFYAK SYFRATFSDG SSRWVIAADE HEAGSQLERH SHSLINLAAD
EDVLDTWFSS ALIPLVIAGW PHNWQADNDH LFPLSLMETG HDILGLWVTR MAMLSLQLTN
RLPFSRIFFH GMVRDSEGQK MSKSRGNVVD PLKLIEGDQE TRIGADALRI SLLRSNPKGD
TVTLDEAVRQ HSRRFCNKLW QSFKYLTKLW NKTEIPLPLK PEPYDSPVDR WILSRLSSLV
IDVHESLEAY NFHLSVEALV NFWWLDFCDI YLEWSKHFFY PKDHLAAAEH MRCMLAMIAS
TYLRLLAPYM PYLAEELYSL LPMADKAVSV HCAPYPTPSE VNFLDPHLEM QMRFVRDLVH
QIRSLRRDVE VSMPIPLVAV AWCNGIQRSA IENFGRLMQR LVEFRCSLND SAEHVPPENS
IMLVSQEECR IYVQLKNVKY EEVLKRFDRQ LEVLERKRTK LTNWMQAKRL HVSPEEAAKK
VTQYLNDIQT VDEEMEKLRR FRRDLHRHHE HAKMLLGLLR VLTFVIMLYY AVLIPFTKVE
ESFNMQAVHD ILFHGFNLSK YDHFEFPGVV PRTFIGPLYL AGIVFPLRLL DYPIKFSKPY
LQLCTRLALG ATVCFGHVRL SRSLKLAFDL NVACWYMAIT LSQFHTMFYA SRTLPNIFAL
ALFLFVVAFY LDGRYYMAAI VATFSATVFR LELAILYAIM FFPILSKWRR RGVKLACIVL
LTGIGFVALS TVIDSYFWNR LVWPEGTVWW YNIVLNKSSN WGTLPFFWYF YSAIPRNLCF
TLCFVPFALF GPEKIRRLTV CALGYVLIYS FLPHKELRFI FYAIPLLNMA ASWVSARMML
MRSSSVPTLI GISLSLVQPM INMLLALCFM RAAIANYPGG EAIVTLHTTL RAEGLSGKPV
RIHIDSYCAE TGVTRFLQVN PLWEYNKSES LILPEQKIDF DYLLIGDSDD VTQVNKNYIT
THRTLYFFHG FAGIEIERNA TFPFLTVQYK LKPRVALLKK EPLITTTVEP VVEA
//
