ID A0A077YZ36_TRITR Unreviewed; 624 AA.
AC A0A077YZ36;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=PH domain containing protein {ECO:0000313|EMBL:CDW53332.1};
GN ORFNames=TTRE_0000159601 {ECO:0000313|EMBL:CDW53332.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW53332.1};
RN [1] {ECO:0000313|EMBL:CDW53332.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW53332.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; HG805849; CDW53332.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077YZ36; -.
DR STRING; 36087.A0A077YZ36; -.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047181; DP13A/B.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR46415; ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2; 1.
DR PANTHER; PTHR46415:SF2; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..416
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 490..618
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
SQ SEQUENCE 624 AA; 71202 MW; 50244AE6783561DA CRC64;
MSKKLFVAYA LQTQCLLKVF EKDTKLLIDF THQLQAHLEL LVSAQADVAA SMEQLSAFLG
GYSNIHFPLT WNNDEFPALI NKFQGTVAEL GSWMELMVQQ LQNCVLYPIS KFVSRLDELQ
TCKESYYAAC HDLNCSLMRV AKLSRKEPAK KVEEGNAEYG ASRRRFHHVG LRYFVLMNSI
QYQRRIGLIE PLLSILYAYR TLFRMGDQAL SHDEELADFF TRVQEQIQRF RLTFLLFIHP
LFTIVSSCFI WTQKLLQARR SFKNFAVFSF HVEQQADSQA SHEYLKTLEE ITRIQSDVYH
SVDSSSVQPS FDERSRHKQG YLFLKSKPSL ISRWDQMYFH TENGNLMCQG KDDVRAASRV
LFELDETVNA REALNEDRRN CFTVTLGSDA KRQFVFQTLS EKECKEWISA VNNIASAGHG
ASSATINDQS EPVPGTRCHD VSKSVEVEVL SAPIQFDMFG LPDTDGSESF SASDKSLKQD
STDVEIFARF STKFLGSIAV SSDRKENITV EAIKKVTHAR MQYNIIRAVD LDLIILKTPP
ELRLLDKDCS AIKAAYRLED IAYWTAHQNN ERMFALLIKQ KGERVEKRDS FTCHVLESTG
IETAEEICGV LGQAMKFVSE SCSS
//
