ID A0A077Z3L6_TRITR Unreviewed; 841 AA.
AC A0A077Z3L6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN ORFNames=TTRE_0000251801 {ECO:0000313|EMBL:CDW54248.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW54248.1};
RN [1] {ECO:0000313|EMBL:CDW54248.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW54248.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; HG805886; CDW54248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077Z3L6; -.
DR STRING; 36087.A0A077Z3L6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00109; Kunitz-type; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 4.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..841
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001728382"
FT DOMAIN 10..188
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 198..406
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT DOMAIN 655..705
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 841 AA; 94680 MW; E0BE13E449952E5C CRC64;
MLVGKAIAAI LLTLCFGCFG KRPDCDRRPL KNSNALKSPG NNGFQVIVKP YPLNGSLDEV
TGYIPGEKYT IVIQGWKTRF TIQTFRGFTL AALSSNDENE PAGLFQLKED GDIRWSVDCW
HAVTHSSMFP KANVSVIWQA PPHDEGCVTF KAAVLEYPNI WYMDDDELTK KLCIRGIASL
IYYNTHKAGY DSPKNLDATE ECCSCDEAKY EVIFDGLWSR QTHPRDYPSL EHLTHFSDII
GASHSRRYIM WAYGGYASDG MKELAEWGST QAYEQEIREQ VGVLIQFAQI CIRGAYLQAS
EVRTIIKARG LWYPNVQGIT RAMFRVDRYH HLVSLASMLG PSPDWVVGLS SFNLCLKNCS
WIDEKTFYLY PFDAGVDSGI TYMSPNNPSI PREPIKAITT KSPADPRSPF YNADSDTLPP
FAKLTFRKDK VYPSECKDSS EYLLASRAST GETETSEDLE NKGKKECTVL NWAPWSLCSA
TCGKGIRMRT RGYKNPVKAH IMGCSRQMNE KQFCNALLSV CHGSENFNDQ CAASPWAQWT
ECSAKCGQGM RSRVRNYLNP MAIKQCSIQL TENENCTGSA GLECNVVEDP HCQATQWSEW
SPCSRSCDEG IRLRTRLLYR PENQESCKHL ELLQKESCNL LSCDTFMRTH AAEICSELME
RGQCEGTFPR YYFDSGTKTC RRFTYTGCKG NRNNFLVRSK TYAYSLVTEV VHEDNDLNAL
RDTTTTRDNG TPKDCVVSGW SDWSECTQTC GRGMKERVRT ILSPARNGGQ PCPVELVEKA
RCRLRPCSVV CRIGSWSSWS ACSASCGTGV QIRQRVAKNP HKQPECPAQQ TEKRMCIESN
C
//
