ID   A0A077Z805_TRITR        Unreviewed;       724 AA.
AC   A0A077Z805;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Anion exchange protein {ECO:0000313|EMBL:CDW55899.1};
GN   ORFNames=TTRE_0000417301 {ECO:0000313|EMBL:CDW55899.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW55899.1};
RN   [1] {ECO:0000313|EMBL:CDW55899.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Aslett M.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW55899.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate host-
RT   pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC       {ECO:0000256|ARBA:ARBA00010993}.
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DR   EMBL; HG805991; CDW55899.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077Z805; -.
DR   STRING; 36087.A0A077Z805; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR   Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR   InterPro; IPR013769; Band3_cytoplasmic_dom.
DR   InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR   InterPro; IPR003020; HCO3_transpt_euk.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR   PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR   Pfam; PF07565; Band_3_cyto; 1.
DR   Pfam; PF00955; HCO3_cotransp; 2.
DR   PRINTS; PR01231; HCO3TRNSPORT.
DR   SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        205..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        397..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        449..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        574..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        629..646
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..128
FT                   /note="Band 3 cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF07565"
FT   DOMAIN          173..233
FT                   /note="Bicarbonate transporter-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF00955"
FT   DOMAIN          234..635
FT                   /note="Bicarbonate transporter-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF00955"
SQ   SEQUENCE   724 AA;  82385 MW;  79557C43D4DC60B0 CRC64;
     MYKSETKLPS IRSPQINLLR KVAKDTEGAC VFIGRPDNIS IPFTQFVRLR NATMMKNLFE
     IPIPLRFLFV LLVPKEHVEK EAEAIARCMG TLFIDEVFSK VCYKARDGNE LCQGIDEFLS
     QCVVVPAGRL SLNCRLEPHE GLLPPVPRSI GKPVDLVLSA VQDHEERLQR TGKLFGGLVE
     DVKIKAKWYW SDFYDAFRGR FTQTVAAAIF LFFANVSKII TFGGVMDHVL QKQMPLCVLS
     ATGPCLVFEV IMNEFCKKHG MDFLTLRLWV GLWTSAWLIL LVAIDASVFV AFITRFTEEA
     FATLISLIFL VKAVEELVEI SHTSPVMTSM ERQLQHVKRR LAKTKCLTIG GAVEGLQCNY
     KPDVFMFSFI LFCGTFFIAE TLKVLRNSRF FTTKVRNTVA DFNVTIAITI MTAAKWFVGV
     DVPCLEVPST FSPTINRSWF LNPVGIEPWW ITLVCILPAT FFSLLILMDQ NITSVIINRP
     ENKLQKHFGY HLDLMVIAIL IAICSFMGIP FYVAATVISL MHADSLRIIS ETTAPGDKPQ
     FLGLKEQRVT ALIAHLLIGV SALLTPFMKV LLTPVLLLIP MPVLLGVFLY MGIVSLSEQQ
     FFQRILIIFM PKKYQPDYLW LRQVQIRRVH LFTAVQVTCF LLLAVVEEYK AISMAFPLML
     VFSVAVRKII LEKIFTSREL QVLDDPLPHW KELLRSKRTS YDKSNLKKIR GQETMLLEVR
     EKNR
//