ID A0A077ZL91_TRITR Unreviewed; 368 AA.
AC A0A077ZL91;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Putative 3-beta hydroxysteroid dehydrogenase {ECO:0000313|EMBL:CDW59390.1};
GN ORFNames=TTRE_0000772401 {ECO:0000313|EMBL:CDW59390.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW59390.1};
RN [1] {ECO:0000313|EMBL:CDW59390.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW59390.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; HG806582; CDW59390.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077ZL91; -.
DR STRING; 36087.A0A077ZL91; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 9..286
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 368 AA; 42484 MW; 71A5C9D514FF5FE4 CRC64;
MTMAKDIVVI TGGSGFLGQH LIREIQELWA DKVDEIRVID KKPFRKILNY NESIPVKEFI
ADIVEEDEID EPLTGATIVF HTAARQFEFG MYANRQKFME DNFQATKQLV FSMVRHRIPY
LIYTGDAFAS LGYEDCAGLS EKSTTKSIDR RYWLLREYGE SKYRSENWLC SKNGPKFVDG
SSVKVIAIRP TLMYGEGENF FLPEVMRLCR KYGFMPHIAA GGVLDTTYAG NVAYMHLLAA
DMLKLHPDEC NGEVVNCNEC TTPSNFYTFL KPFVEASGYQ LKELPLPYLP TLALLYLVQL
FLKLIWLIFG STSNFDLPNV STLIYFCYHY LYVNSTKARL LLNYKPKYQP EDTMQRTLQW
WKANCAHY
//
