ID   A0A078B7T7_STYLE        Unreviewed;       719 AA.
AC   A0A078B7T7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN   Name=Contig14624.g15575 {ECO:0000313|EMBL:CDW90580.1};
GN   ORFNames=STYLEM_19725 {ECO:0000313|EMBL:CDW90580.1};
OS   Stylonychia lemnae (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX   NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW90580.1, ECO:0000313|Proteomes:UP000039865};
RN   [1] {ECO:0000313|EMBL:CDW90580.1, ECO:0000313|Proteomes:UP000039865}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=130c {ECO:0000313|EMBL:CDW90580.1,
RC   ECO:0000313|Proteomes:UP000039865};
RA   Swart Estienne;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CCKQ01018608; CDW90580.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A078B7T7; -.
DR   EnsemblProtists; CDW90580; CDW90580; STYLEM_19725.
DR   InParanoid; A0A078B7T7; -.
DR   OrthoDB; 2877219at2759; -.
DR   Proteomes; UP000039865; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF7; SD02261P; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000039865};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        157..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        542..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          435..569
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
SQ   SEQUENCE   719 AA;  83808 MW;  D10E3BB0A9650A73 CRC64;
     MKILRICQQS IILEGLQTLL IKKRRKQTKM KLRLLITTEK LKLNGIRCFQ MTQLDNQGLI
     IQPDMFVSYL EEVPKNDQIE YQISSTDLGP FSKYQDQALK INYTITHNVP RESNSDSDCL
     NWYINQNYDF SLRSAIRLTI DFTKQPCHLD SYNLVEFLWV SAGVIIFALL SIILQVKYLF
     SIKARYERLR KKYNKKLNKD LNSHEKAQKI ISPKNQKLLK SYTRIQDKNS KYLSMVRKQS
     IVDSRQGDNN PFNMSINEEE EEKEEIVMSV TTSTYFGYNP DKEIENDNNN SVKINKTTEE
     ASRKGVRRST TINTQINRKY SQQFDQGYQG NAGRILGEKV PTLVRQENKK GTNTNFDVED
     ISLINIQPEQ QQQNENGQDI IDNEQIFQQK KLAWDDLSFS DRSRLINKFC FIAILGNLFQ
     IIGTIMYLLR PIRETSVEDA LMGLGCLLAW STLPRYFMFS QKYSLILRTM EYSFPVLMKA
     LLGIIPFFIG YAILGQCLFW PFQKRFGSFS MALMTLFCMM NGDNLVPVHR DLSQYDVLWG
     NLYLYVYIFL SIVVIMNIFI IIIEQGYLTI KYKKAYDWLE EDDKGDIQSN LNVPEEIRIG
     SGNQEAFERD MFSKLRDAFE GITDGNQYGK GEPVDNHPMP KQFQRTITSQ QSFASRGLKP
     QNSLVYKNQS VNKKEFKRQQ SKIIFKDLIF DEDKAFKNAA QNIQKEPLLL QSKKNSQPQ
//