ID   A0A081BHW9_9LACO        Unreviewed;       905 AA.
AC   A0A081BHW9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Predicted drug exporter of the RND superfamily {ECO:0000313|EMBL:GAK47637.1};
GN   ORFNames=LOSG293_100020 {ECO:0000313|EMBL:GAK47637.1};
OS   Secundilactobacillus oryzae JCM 18671.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Secundilactobacillus.
OX   NCBI_TaxID=1291743 {ECO:0000313|EMBL:GAK47637.1, ECO:0000313|Proteomes:UP000028700};
RN   [1] {ECO:0000313|EMBL:GAK47637.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG293 {ECO:0000313|EMBL:GAK47637.1};
RA   Tanizawa Y., Fujisawa T., Mochizuki T., Kaminuma E., Nakamura Y., Tohno M.;
RT   "Draft Genome Sequence of Lactobacillus oryzae Strain SG293T.";
RL   Genome Announc. 2:e00861-14(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAK47637.1}.
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DR   EMBL; BBJM01000010; GAK47637.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A081BHW9; -.
DR   STRING; 1291743.LOSG293_100020; -.
DR   eggNOG; COG2409; Bacteria.
DR   Proteomes; UP000028700; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        247..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        291..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        735..754
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        761..781
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        793..818
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        839..859
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        865..888
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          78..377
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          635..807
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   REGION          547..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          486..513
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   905 AA;  100354 MW;  C2D9D666DF856BAF CRC64;
     MHEGTGQHMQ ERIQKLHDYR IFSLIVWLVV IFIAIISMPK TSTIVQYFGQ PQLTSTSQPA
     KAQKIKNVWG RDLNGTYTVN AVFNNPKGKL TTNQQIEIAR VVAKLQGKQK FYGIKKITTA
     TNTPEAKNQL ISKDQSTQIV QLAVTREQGT VRTLSKQLYS QVQTASLKAY VTSPEIINDN
     NNARIAGYIQ IAAIILFIFA MITLGILFQS VAVPIISLIT LLISYVTSLS LANNLTYRGN
     FPYSEYLPLA ILLGTIIVGT FELFFIYRRF KINLVEGMEA PAVTSRSMRY VRYPIIAVGV
     VLTLIFGSFW FLPFSTIRSF SSLALTFIVL TLAILTIPPI FMGMLEENFF WPTADRLKTT
     ERHFWGRLAK FGLWQPIVAV IVVLYLVGPF AYSYRNNLSY SVMDNLTTEN QAAKGAKVLA
     AHFSQGKATP VSVYIKSDKR LDSANALYQI DNLTTKLKSM PGVQSVTSLT QPDGMPVSQN
     YVSNQLLDLN QDLKGANDKL KSLQSDLKDN RSDLDVNTLK DINDSLTKLA TSASELSSDT
     GSVQSQVSSI TSAANQTQQS NSARRTAAYN RQVSALATQL TTIASNVQTL TTEASSSQSS
     VSSYRSKVES IAKSLKASQT SLKEMTSRFD GIYNYLGKLQ ASDAAKIYFM TPEQIMTPTF
     QRTVINNTSQ NGKTTMLTVY LKKSADSHET LAITQKLQDQ IQTQLQGTSL KKATVAITGQ
     PVVQSEIQSS FERNLPRMIL IVVGLMLLGL MIISRSVLQP AFWGATFLLS SLAGLQLAHL
     TMRFTSGDPQ FNWQVIVLAM VPLTALAALQ LIPLAIDYRY NEDSLLEWLL PAMSNSGQTL
     RHTLFISFMA VFGLAFLRFE PLSEIVLIFI FTAIIFNLAL PVMVAALGKL TVTLPARKPH
     FRRHG
//