ID A0A083ZUX4_9GAMM Unreviewed; 394 AA.
AC A0A083ZUX4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Multidrug export protein EmrA {ECO:0000313|EMBL:KEY56853.1};
GN Name=emrA {ECO:0000313|EMBL:KEY56853.1};
GN ORFNames=SRDD_42540 {ECO:0000313|EMBL:KEY56853.1};
OS Serratia sp. DD3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=1410619 {ECO:0000313|EMBL:KEY56853.1, ECO:0000313|Proteomes:UP000017810};
RN [1] {ECO:0000313|EMBL:KEY56853.1, ECO:0000313|Proteomes:UP000017810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD3 {ECO:0000313|EMBL:KEY56853.1,
RC ECO:0000313|Proteomes:UP000017810};
RX PubMed=25212623;
RA Poehlein A., Freese H.M., Daniel R., Simeonova D.D.;
RT "Draft Genome Sequence of Serratia sp. Strain DD3, Isolated from the Guts
RT of Daphnia magna.";
RL Genome Announc. 2:e00903-14(2014).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEY56853.1}.
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DR EMBL; AYKS02000115; KEY56853.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A083ZUX4; -.
DR STRING; 1410619.SRDD_42540; -.
DR eggNOG; COG1566; Bacteria.
DR Proteomes; UP000017810; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..351
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 214..296
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 394 AA; 43118 MW; 9D3FC58578251F54 CRC64;
MGSMNTNAGT QVAQQPANSK KQQRTFWLLL LTVIFIIIGV VYLVYWFMVL RHHQETDNAY
VAGNQVQIMA QVSGSVNSVA FDNTDFVHQG DVLLTLDPAD AEQAFARAKT ALANSVRQTH
QLVVNSKQYQ ANIALRKSEL SKVESDLQRR IVLGHADAIG REELQHAKNA VDNAKAALEV
AIQQYNANQA LVLNTPLEEQ PAILQAAAQM RDAWMALQRT RIVSPVTGFV SRRSVQVGAQ
ISTETPLMAI IPAELMWIDA NFKETQLTNM RIGQPATVVT DIYGSEVVFK GKVVGIDMGT
GSAFSLLPAQ NATGNWIKVV QRLPVRIELD AQQVAEHPLR IGLSTLVKVD TANQDGPVLA
NTVRKEPRYE TSALTLDLAP VNQMIADVIH ANAG
//
