ID A0A084JCS0_9CLOT Unreviewed; 874 AA.
AC A0A084JCS0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=IO99_08575 {ECO:0000313|EMBL:KEZ86754.1};
OS Clostridium sulfidigenes.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=318464 {ECO:0000313|EMBL:KEZ86754.1, ECO:0000313|Proteomes:UP000028542};
RN [1] {ECO:0000313|EMBL:KEZ86754.1, ECO:0000313|Proteomes:UP000028542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=113A {ECO:0000313|EMBL:KEZ86754.1,
RC ECO:0000313|Proteomes:UP000028542};
RA Honkalas V.S., Dabir A.P., Arora P., Dhakephalkar P.K.;
RT "Draft genome of Clostridium sulfidigenes 113A isolated from sediments
RT associated with methane hydrate from Krishna Godavari basin.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEZ86754.1}.
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DR EMBL; JPMD01000018; KEZ86754.1; -; Genomic_DNA.
DR RefSeq; WP_035132278.1; NZ_JPMD01000018.1.
DR AlphaFoldDB; A0A084JCS0; -.
DR STRING; 318464.IO99_08575; -.
DR GeneID; 84601084; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000028542; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000028542}.
FT DOMAIN 687..703
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 503..549
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 874 AA; 99437 MW; 997891AE9D6B0367 CRC64;
MALTPMMQQY FQIKDKYKEC ILFFRLGDFY EMFFDDAKVA SKELELTLTG RDCGLEERAP
MCGIPFHAAK NYIGALISKG FKVAICEQVE DPAVAKGIVK RDVVKIYTPG TYTEASYLDE
SKNSYTASLY VKENHIALAF CDVSTGDFYT TEFKYNINVL IDELCKFNPR EIIITENFNQ
EIMDEIISRT SFYISHFQDD NFNMEEEDLK EQFLNIEIDK LSEIVTKTCN GLIRYIKETQ
KVSLTHINHI EIYDICTYMT IDVNSRRNLE LVENIRDKGK TGTLLWVIDK TNTSMGGRRI
RKWLEEPLII KEDILNRQDA IEEFTKNIIL MEDLKEALNS IYDIERLVGK ISSTAINAKE
LISLKHSIAK VPRIKELISN LTSPLMKDVY SNLDELRDIW TFLESSIMDE PSLSVKEGNI
IKTGYNSLVD ELRESKTNGK LWLANLENEE RIATGIKSLK ISYNKVFGYY IEVTKSNLSS
VPEGRYIRKQ TLSNAERYIT PELKEMEDKI LGAEEKLIAL EYSIFTEIRE KLEENIERMK
NTAKLISEID CIWALAMVAR EHNYVKPVIN TEGIIEIQDG RHPVVEVITK ANSFISNDTT
LDLEDNRLML ITGPNMAGKS TYMRQVALIT LLAQMGSFVP AKEANVSICD KIFTRIGASD
DLAGGKSTFM VEMWEVSNIL NNATNKSLVL LDEVGRGTST YDGLSIAWAV IEYICKNSNI
KCKTLFATHY HELTKLEGEI PGVKNYSISA KKVDNNIIFL RKIIKGGADE SYGIEVAKLA
GLPSAVITRA REILETLEDG TSKDIIKEEA KTVIPTTEKL EKIEKEICLT QQIAFEDVAM
QNLIDEIKSI DVLNLTPMDG FNKLYDIIKK AKNI
//
