ID A0A084VBA7_ANOSI Unreviewed; 477 AA.
AC A0A084VBA7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KFB35251.1, ECO:0000313|EnsemblMetazoa:ASIC001421-PA};
GN ORFNames=ZHAS_00001421 {ECO:0000313|EMBL:KFB35251.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB35251.1};
RN [1] {ECO:0000313|EMBL:KFB35251.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC001421-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01006259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524349; KFB35251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VBA7; -.
DR STRING; 74873.A0A084VBA7; -.
DR EnsemblMetazoa; ASIC001421-RA; ASIC001421-PA; ASIC001421.
DR VEuPathDB; VectorBase:ASIC001421; -.
DR VEuPathDB; VectorBase:ASIS006943; -.
DR OMA; MQRGLLM; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF0; SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 322..417
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 412..461
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 50694 MW; BD55752C924EBD8B CRC64;
MSESPPPPQQ HALSGGTVSP GRPLSPPLPT VSSPNPVTDD PAFIPLNMLS LVASAGGTAG
ATTTPPQPAG MALPVPAESF SSLLHNHHHH LHHHHHHAMA AAALVAADHH HHPSFFFPAA
TTASPTVGGS AAGASAHVVG PSVSGGSVVA GSGSSLFAPH SSPNGVILLS DPTGVFDLAS
DDFSLEDCDE RARIQRELEI REGVDAPPNF HPRRLMSGGT ISAGPAANHP IAFFYSRDLM
QRGLLMANRF IQPLDAAAGG CPAGAAAMAA AAAAAAAAAG RGGAGGGAVG AAAAFGGLRI
HSQVDFIHCL VPDLQKITSC SFYWGKMDRY EAERLLEGKP EGTFLLRDSA QEEFLFSVSF
RKYNRSLHAR IEQFNHKFSF DSRDPGVYTA STVTGLLEHY KDPSCVMFFE PMLTYPLNRN
FSFSLQQLCR AAIVSNTTYD GINELALPKS LKAYLKEYHY RQRVRFRPLD EHLYSNA
//
