ID A0A084VHY6_ANOSI Unreviewed; 676 AA.
AC A0A084VHY6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN ORFNames=ZHAS_00004820 {ECO:0000313|EMBL:KFB37580.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB37580.1};
RN [1] {ECO:0000313|EMBL:KFB37580.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC004820-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001031};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-
CC fructose 6-phosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004775}.
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DR EMBL; ATLV01013250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524847; KFB37580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VHY6; -.
DR STRING; 74873.A0A084VHY6; -.
DR EnsemblMetazoa; ASIC004820-RA; ASIC004820-PA; ASIC004820.
DR VEuPathDB; VectorBase:ASIC004820; -.
DR VEuPathDB; VectorBase:ASIS023477; -.
DR OMA; EWYLASD; -.
DR UniPathway; UPA00113; UER00528.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00714; GFAT; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR005855; GFAT.
DR InterPro; IPR047084; GFAT_N.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035490; GlmS/FrlB_SIS.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR NCBIfam; TIGR01135; glmS; 1.
DR PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR PANTHER; PTHR10937:SF0; GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); 1.
DR Pfam; PF13522; GATase_6; 1.
DR Pfam; PF01380; SIS; 2.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS51464; SIS; 2.
PE 4: Predicted;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..282
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT DOMAIN 354..494
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 525..666
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 676 AA; 75402 MW; 2D588C4F7244778A CRC64;
MCGIFAYLNF LTPKSRREVL ELLLNGLKRL EYRGYDSAGV AVDGIAADAG ILLFKRTGKV
KVLEDAIREA AKEIDFSEAC DTHVGIAHTR WATHGAPSEL NSHPQRSDDT NAFVVVHNGI
VTNYKDIKKF LELRGYSFES DTDTETIAKL VHHLWKQHPN YSFRELVEQV IQQLEGAFAL
AFKSKHFPGE CVVTRRGSPL LVGIKAKTSL ATNHVPILYG KGPRHGSLGN VQVEPTPDNT
ADFINPGEEV EYFFASDASA VIEHTNRVIY LEDDDVAAVK DGALGIHRLK KSLDDPHARE
ITTLKMEIQQ IMKGNYRYFM QKEIFEQPES VVNTMRGRVN FDSKKVTLGG IKDYIPEIKR
CRRLMLIACG TSYHSAVATR QLLEELTELP VMVELASDFL DRNTPIYRDD VCFFISQSGE
TADTLMALRY CKQRGALIVG ITNTVGSSIC RESHCGVHVN AGPEIGVAST KAYTSQFISL
VMFALVMSED RLSLQSRRLE IIEGLRNLDA HIKQVLQLDQ KVLEIAQDLY QQKSLLIMGR
GFNFATCMEG ALKVKELTYM HSEGIMAGEL KHGPLALVDD TMPIVMIIMR DPVHLKCMNA
LQQVTAREGR PIIICEEGDN ETMAFASKAL EIPRTVDCLQ GVLTVIPMQL LSYHIAVLRG
CNVDCPRNLA KSVTVE
//
