ID A0A084W518_ANOSI Unreviewed; 2176 AA.
AC A0A084W518;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN ORFNames=ZHAS_00013259 {ECO:0000313|EMBL:KFB45312.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB45312.1};
RN [1] {ECO:0000313|EMBL:KFB45312.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC013259-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01020452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525302; KFB45312.1; -; Genomic_DNA.
DR STRING; 74873.A0A084W518; -.
DR EnsemblMetazoa; ASIC013259-RA; ASIC013259-PA; ASIC013259.
DR VEuPathDB; VectorBase:ASIC013259; -.
DR VEuPathDB; VectorBase:ASIS008032; -.
DR OMA; QTEIQYY; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 522..705
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 716..953
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1369..1545
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1578..1786
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 51..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..240
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2176 AA; 247362 MW; 28714472F6417A8E CRC64;
MADAAARQLQ YEYKANSNLV LQADIRLIER PRRDEATGEV ISLVGKLDGT RMGDRAQRSK
PEKTEERKAK RQKRDEAQYD FNSMKGATLL SEGIDEMVGI VYRPKTQETR QTYEVLLSFI
QEAIGDQPRD ILRGAADEIL AVLKNDRMKE REKKREIDGL LGSVADERFA LLVNLGKKIT
DFGSDAASAI GTVGQAGPGG DEPIDEQYGI NVRFEESEEE SDEDKYGEVR EDDGQDEGEE
ARDDGILHAE NLAGGEDMNK KEKALDPRDI DAHWLQRCLR KYYNDSMMSQ AKALEVLSVL
KESGDDRECE NQLVLLLGYD CFDFIKQLKK NRQMILYCTM LAQSQSESDR IKLREKMKSD
AALAKILRQL DTGKQEAQEG REYGNGSEMD GSDTKSASLR ARRERLEDAF MDDSEGPRGG
AGGGEGVSGA GGQIMGNRTV LELDELAFTQ GSHLMANKRC QLPDGSFRKQ RKGYEEVHVP
ALKPRPFDDD EELIAIEKLP KYVQPVFSGF KTLNRIQSRL YKSALESDEN LLLCAPTGAG
KTNVALLTMM REIGKHINDD GTINVDEFKI IYIAPMRSLV QEMVGNFGRR LATYNLTVAE
LTGDHQLSRE QIAATQVIVC TPEKWDIITR KGGEKTYTQF VRLVIIDEIH LLHDERGPVL
EALVARTIRN IETTQEDVRL VGLSATLPNY QDVATFLRVR PETGLFYFDN SYRPVALEQQ
YIGVTEKKAL KRFQVMNDIV YEKVMEHAGR NQVLVFVHSR KETGKTARAV RDMCLEKDTL
GSFLREGSAS MEVLRSEADQ VKNQELKDLL PYGFAIHHAG MTRVDRTLVE DLFADRHIQV
LVSTATLAWG VNLPAHTVII KGTQVYNPEK GRWVELGALD VLQMLGRAGR PQYDTKGEGI
LITNHSELQY YLSLLNQQLP IESQLISKLP DMLNAEIVLG TVQNVKDAVT WLGYTYLYIR
MLRQPTLYGV SIDAVQDDPL LEQFRADLIH TAALHLERSG LLKYDRKSGH FQVTEVGRIA
SHYYCTHETM LTYHQLLKPT LSEIELFRVF SLSGEFRNIT VREEEKLELQ KLMERVPIPI
KESIEEPSAK VNVLLQAYIS QLKLEGFALM ADMVYVTQSA ARLLRAIFEI VLHRGWAQLA
DKCLTLCKMI DRRMWQSMSP LRQFRKMPEE IVKKIEKKNF PWERLYDLEA NEIGELIRVP
KLGKTIYRYI HQFPKLELST HIQPITRSTL RVELTITPDF QWDEKVHGQS EAFWILVEDV
DSEVILHHEY FLLKAKYCTD DHLVKFFVPV FEPLPPQYFL RIVSDRWIGA ETQLPVSFRH
LILPEKNLPP TELLDLQPLP ISALREATFE ALYSDRFPQF NPIQTQVFNA VYNSEDNVFV
GAPTGSGKTT VAEFAVLRLL SQNPAGRVVY LVARDPLAEL VFHEWHQRFG QSALGCKVVK
LTGETGTDLK LIAKGQIIVT TADKWDVLSR RWKQRKNVQN VQLFIVDELQ LIGGEDGPVL
EVVCSRMRYI SSQIEQPIRI VALSASLADA RDIAQWLGCS TNATFNFHPS VRPIPLELHV
QGLNITHNAS RIAAMSKPVY NAITKFSPHK PVIVFVTSRK LARLTAIDVL TYCAAELQPN
RFFHAEEDDI KPFLDRMTDK TLKETLSQGV AYMHEGLTAS DQRMVEQLFD SGAVQIAICT
RELCWALNIS AHLVIIMDTQ FYNGRTHSYE DYPITDVLQM VGRANRPLED DDAKAVLMCQ
SSKKDFYKKF LNEPLPVESH LDHRLHDHFN AEIVTKTIEN KQDAVDYLTW TFLYRRLTQN
PNYYNLQGVT HRHLSDHLSE LVESTLSDLE QSKCIGVEDE MDTLPLNLGM IAAYYYINYT
TIELFSLSLN SKTKIRGLLE IISSAAEYED LIVRHHEDNL LRSLANRLPN KLTGPNGTAP
KYNDPHIKTN LLLQAHLSRL QLGAELQGDT EQILGKAIRL VQACVDVLSS NGWLSPAVAA
MELAQMVTQA MWSKDSYLKQ LPHFSADIIK RCQEKKIETV FDIMELDDDD RTRLLQLTDQ
QMSDVARFCN RYPNIELTFE VLDKERIHSG SSVNVAVNLE REDDVTGPVI APFFPQKREE
GWWVVIGDPK TNSLLSIKRL TLQQKAKVKL NFVAPSPGHH EYTLYYMSDS YLGCDQEYKF
SINVGDFQSE SESESD
//
