ID A0A084WCU3_ANOSI Unreviewed; 518 AA.
AC A0A084WCU3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Deoxyribodipyrimidine photo-lyase {ECO:0000256|ARBA:ARBA00014046};
DE EC=4.1.99.3 {ECO:0000256|ARBA:ARBA00013149};
DE AltName: Full=DNA photolyase {ECO:0000256|ARBA:ARBA00031671};
GN ORFNames=ZHAS_00016157 {ECO:0000313|EMBL:KFB48037.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB48037.1};
RN [1] {ECO:0000313|EMBL:KFB48037.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC016157-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in
CC DNA).; EC=4.1.99.3; Evidence={ECO:0000256|ARBA:ARBA00033999};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-2 family.
CC {ECO:0000256|ARBA:ARBA00006409}.
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DR EMBL; ATLV01022885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525337; KFB48037.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WCU3; -.
DR STRING; 74873.A0A084WCU3; -.
DR EnsemblMetazoa; ASIC016157-RA; ASIC016157-PA; ASIC016157.
DR VEuPathDB; VectorBase:ASIC016157; -.
DR VEuPathDB; VectorBase:ASIS018219; -.
DR OMA; IHNYLRM; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0003904; F:deoxyribodipyrimidine photo-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR008148; DNA_photolyase_2.
DR InterPro; IPR032673; DNA_photolyase_2_CS.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00591; phr2; 1.
DR PANTHER; PTHR10211:SF0; DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; 1.
DR PANTHER; PTHR10211; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS01083; DNA_PHOTOLYASES_2_1; 1.
DR PROSITE; PS01084; DNA_PHOTOLYASES_2_2; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 79..211
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 59481 MW; 3C0F1886543C9B36 CRC64;
MKKSASASSS SIGPAAKKQK PNEPEPPVEA ASASKTNDNY VALFKADRKA TAKSVLDFDF
KKKRVRVLSD AKEVEEGKKG VVYWMSRDVR VQDNWAFLFA QKLALKNELP LHVCFNLVPK
FLDATIRHFK FMLKGLEEVA QECGQLNIQF HLLRGNAAQN VPEFVQQHNI GAVVCDFSPL
RVPAKWVEDV RKALPLEVPL CQVDAHNIVP VWVTSDKLEY AARTIRNKVN NNLSTYLTPF
PPVVKHPYTA SSQANPIDWA KVLDTLEVDR SVDEVTWATP GYEGGVRTLQ SFVEKRLVKF
NSKRNDPTQN ALSNLSPWFH FGQLSVQRAI LTVKSYGKRF NESVASFCEE AIVRRELSDN
FCFYNKNYDN LQGAYDWARK TLDDHRKDKR VYCYSRDELE TAKTHDDLWN AAQLQMVKEG
KMHGFLRMYW AKKILEWSKT PEEALEAAIY LNDRYSLDGR DPNGYVGCMW SIAGIHDQGW
KERDIFGKIR YMNYEGCKRK FDVNAFVIRY GGKVHRRK
//
