ID A0A084WPQ6_ANOSI Unreviewed; 728 AA.
AC A0A084WPQ6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial {ECO:0000256|ARBA:ARBA00013888};
GN ORFNames=ZHAS_00020307 {ECO:0000313|EMBL:KFB52200.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB52200.1};
RN [1] {ECO:0000313|EMBL:KFB52200.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC020307-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the complex I 75 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00005404, ECO:0000256|RuleBase:RU004523}.
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DR EMBL; ATLV01025119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525369; KFB52200.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WPQ6; -.
DR STRING; 74873.A0A084WPQ6; -.
DR EnsemblMetazoa; ASIC020307-RA; ASIC020307-PA; ASIC020307.
DR VEuPathDB; VectorBase:ASIC020307; -.
DR VEuPathDB; VectorBase:ASIS024442; -.
DR OMA; QDQAMAY; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR CDD; cd02773; MopB_Res-Cmplx1_Nad11; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.200.210; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR000283; NADH_UbQ_OxRdtase_75kDa_su_CS.
DR InterPro; IPR010228; NADH_UbQ_OxRdtase_Gsu.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR InterPro; IPR015405; NDUFS1-like_C.
DR NCBIfam; TIGR01973; NuoG; 1.
DR PANTHER; PTHR43105:SF13; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR Pfam; PF09326; NADH_dhqG_C; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00641; COMPLEX1_75K_1; 1.
DR PROSITE; PS00642; COMPLEX1_75K_2; 1.
DR PROSITE; PS00643; COMPLEX1_75K_3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT DOMAIN 34..112
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 112..151
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 253..309
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 728 AA; 79382 MW; 82411B4D6D5AE8CC CRC64;
MLRVPVTRAL ALGARYPMQT IVRTSATTPA KLPEKIEVFV DDQPVMVDPG TTVLQAAAQV
GVEIPRFCYH ERLAVAGNCR MCLVEVEKSP KPVAACAMPV MKGWRIKTNS EMTRKAREGV
MEFLLMNHPL DCPICDQGGE CDLQDQAMAF GSDRSRFTDI HHTGKRAVED KDIGPLIKTI
MTRCIHCTRC IRFASEVAGV DDLGTTGRGN DMQIGTYVEK FFLSELSGNV IDLCPVGALT
NKPYSFVARP WEIRKIESID VLDALGSNIV VSTRTGEVLR ILPRENDAIN EEWLSDKSRF
ACDGLKRQRL IAPMLRNPSG DLEAVEWESA LITIAQALRG APKGKVAAVA GGLADAEALV
ALKDLLNRLG SETLCTEQKF PTDGSGTDFR SSYLLNSSIA ACEEADLVLL VGTNPRYEAP
LLNTRLRKGY IHNEQNIALI GPKVDLSYDY EHLGSDTSLI RDIANGNHPF AKKLKEAKKP
LIIVGANQLA RKDGSSFLTA LHVFANSLSP ADKNWKVWNV LQTNAAQTAA LDVGYTPGMD
AVYELQPKVL FLLGADGGVV DKEKLPKDCF IVYQGHHGDV GAQQAHAILP GAAYTEKQGT
YVNTEGRAQQ TLVAVTPPGL AREDWKILRA LSEVAGTPLP YDNLDELRAR LEDVAPHLVR
YGRLEAANFF SIADALLKNA SVSFDGSKVD VGQKKLSDFF MTDPITRASP TMAKCVTAAK
KQATQAAH
//
