ID A0A085MXC6_9BILA Unreviewed; 664 AA.
AC A0A085MXC6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 44.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFD61872.1};
GN ORFNames=M513_12132 {ECO:0000313|EMBL:KFD47002.1}, M514_12132
GN {ECO:0000313|EMBL:KFD61872.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD61872.1};
RN [1] {ECO:0000313|EMBL:KFD61872.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD61872.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD47002.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; KL363344; KFD47002.1; -; Genomic_DNA.
DR EMBL; KL367608; KFD61872.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085MXC6; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF99; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..664
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010405305"
FT TRANSMEM 281..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..194
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 280..478
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 54..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 78..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 86..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 123..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 150..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 154..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 664 AA; 71046 MW; 4EEE067A068D3FB6 CRC64;
MAAGRIALAG CLLIVGAAHL SPVGDTVATA TAGGAAVGGG GGGEPYLLHR QPSVGAASSS
SSSSSSSSAS IGGGGGGCQH VEVSMCKDLP YNYTSVPNFV GNEEQSEAEL QLSTFLPLIQ
LQCSSQLKFF LCSVYVPMCT DKVDIPIGPC RPLCESVRRC CEPMLRQFGF PWPASLNCSK
FHPENNAQAM CMRGPSEDHS SLCFGDTYPA AVAVEDSTTS IIVGTERPGR RLSISNSYGP
CSHLRDGGRN FVRLNKTGGQ CAQLCHADVL FSVEQKRNAE VLMLVFAAAC SVLCVAALAF
QFCKPRVALH YPDVAILYIC ICYASATVPY WIRAAGREAL TCSGYGYHQQ QQQYVIAGFG
LQHVRCTVVS ISLYYFTMAS HVWWIILCAC WLLIGSLGFS AQSIQRQSFT FHCVAWILPL
IKVIVVFIMQ TVDADELTGM CFVGNQSRQG LQFLLVPQTV YLVAGLVPLT LGFVIKLRDC
LGGGNAGSSL PSQPITSSSG PAVDRRQPTT FVKPNLWQQT PAGASLTSTG LLAAFYVVPH
GCLLACYAYE YFNRDDWLKY AGKQPSYETF VVKIVAVFVY GIACGGFLLW RRTCDRSVLT
RAPAKAPSAL PVAGGRYAFG SAAAAASQRV ALLSEHKYGV ASATMRMHST APAGGHFPCV
DHML
//
