ID A0A085ND65_9BILA Unreviewed; 1330 AA.
AC A0A085ND65;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Integrase core domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M514_20447 {ECO:0000313|EMBL:KFD67411.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD67411.1};
RN [1] {ECO:0000313|EMBL:KFD67411.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD67411.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
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DR EMBL; KL367515; KFD67411.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09272; RNase_HI_RT_Ty1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR025724; GAG-pre-integrase_dom.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR013103; RVT_2.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR42648:SF11; TRANSPOSON TY4-P GAG-POL POLYPROTEIN; 1.
DR Pfam; PF13976; gag_pre-integrs; 1.
DR Pfam; PF14223; Retrotran_gag_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF07727; RVT_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 198..213
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 424..589
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 662..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 151342 MW; 1427AA69C983DE54 CRC64;
MTVLLVRRIP FKQFLTECGA KYEYTWRGAI QQVINNSAQL RGNGSLENIK LLHLTELESA
REMWQTLQRL HERSSIGSRL YLKRKLYGMR FTHGTMQAHL NAILEIVAQL RGMGKNIEED
DLSPILLTAL EGKDEADLSV EYVSGKLLDE YQRRVESGRS ENAGSGIAMK STARNEYGQA
EAIKAARNRS IKPEDRECYF CRKKGHIKVN CRKYKRLLEK GDRAGHMVSD RKRRGEAHNV
NAVADATHHL SFAAYERASM ASNAQWYVDS GATSHMTNDK NFFTSLQPAK TTILLKEVLY
VPSLESGLLS VQRMTSRGCT VTFKKDTCLI SWKSNVIAMA AMDGALFKLK HQLRTDTAFT
VKKKACIHTW HRRLGHRDLA AVRKQSDEQL ADGIHLAKCD GEIDCEVCIK GKLAQPPFPT
SDSRAMKPTE LVHSDVCGPM PTATPSGHRY MLTFIDDYSR FTFVRLLKAK DEVADVVKEY
VAKVKTKFGH NPVTFRTDNG KEYVNWELQD FFKRNGIEHQ FSAPYTPQQN GVAERKNRAL
VEMAKCMLID AKLPERFWGE AVCTAAYLQN RLPSRKLLKT PFEIWTGKRP SLNHIRIFGS
KAYSLVPQQR RKKWDDRAIQ GTLVGYDNAT KGYRLLDPVS NKIWISRSVR IIEEDQQHAK
SIEKEVKTSE GAKELTLKEE IDESDDPSKH GTDVNVEDVF GSSWHESQLE RGIEAPRRSQ
RANKGVPPQK LSYKVKTEKA SEPSSWEEVL DLPPCEREKW IAAAKEELAS LKNREVWELV
QLPAGREVIS SKWVFKLKKS ADDTLGTYKA RLVARGFSQR YGEDYDETFA PVVKHETIRM
LLSIAAIRSL HVRHFDVKCA YLNGEIHEEL YMQQPPGFEE PGNENHVLRL KRSIYGLKQS
ARAWNKKATE TLLKLGFDRA KADLCLYMRK ESTDSTTYVL LYVDDLLVAG ESEAITRSVG
AQLNKHFITK DLGKVSNYLG IQIERKEDGT FLLHQRCKIE QLLEKLGMSE VKPKGTPMET
GYLSTMNESN VPLPNNVKYR QVIGSLLYIA TVSRPDIALA VGLLCRRVES PTEYDWKSAK
RVLRYLTGTK ELKLCLSAMS NPVLQGYVDA DWAGDRTDRK STSAYLFQFG ESIISWSTKK
QTTVALSSTE AEYIAMAEAC KELLWLRQLL EDFGIPQMNA TTIFEDNQGC ICLVKSERFT
NRTKHISVKY HLLKDLRERR IINVKYCPSD QMIADALTKP VSKEQLNRFA RQIGLMNWHI
FGNRENNNRL NNTRICTKTL PKKILKGSFT YLVCWSAQSV TAMDAAAKQR SILPASTAQP
KQNGFTVWPR
//
