ID   A0A085NE21_9BILA        Unreviewed;      1398 AA.
AC   A0A085NE21;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Guanine nucleotide exchange factor DBS {ECO:0008006|Google:ProtNLM};
GN   ORFNames=M514_12898 {ECO:0000313|EMBL:KFD67717.1};
OS   Trichuris suis (pig whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD67717.1};
RN   [1] {ECO:0000313|EMBL:KFD67717.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD67717.1};
RX   PubMed=24929829; DOI=10.1038/ng.3012;
RA   Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA   Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA   Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT   "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL   Nat. Genet. 46:701-706(2014).
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DR   EMBL; KL367511; KFD67717.1; -; Genomic_DNA.
DR   Proteomes; UP000030758; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 1.20.58.60; -; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR22826:SF201; LD43457P; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          932..1116
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1337..1398
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          872..906
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1281..1305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..906
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1289..1303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1398 AA;  158622 MW;  0D7F09F469C7BC41 CRC64;
     MAEADCEATN PTEAFRYSNG SFREPSWRAS YHYDFDFDLQ LLKVKNMVWS SREAIFNSAP
     TSQRILRADL EESGYQSALT RSQNSQYGTG WLYHDSESIA STSSCDEWDG YMTIDNERIK
     IREVSDLLVT RYAFISGAKS EQGLPVLTFP DSHVQFSFAD YRILVNYLAR LQPVEDIFNG
     FVAIIDRRTD RWSSVKTVLS YLTLFFPGSL RVAYVLKPDG VLQRALEVGY KRISEAKRFQ
     VFVCNNLLEL HRYVHPSRLT VDLGGSFCYN HLEWLQHRMV EVERLRCSAE GIARTLDEFV
     QSLKDTELPN DASTTAHILT SQRTDRDAIK ANLQEDFRIV VRRGFDLLKA VRQVDSKPNA
     DQLSPTRLHN VTSVQRTLLQ LEDAEKSFDK FWPDHELRLE HCLRLRQFEE DFKKLHKLRS
     LNTKRFCLFT RSRAPSSRLL IDKGTTTDCV LPPSRCSGTT KLAFFLVSRI CDSLRQKIVS
     VFKSREPIAS GWALSRIPKF SCCNLTCRVN ALLENRINGL APRVGKCAPC RRHVSIGCSA
     FRATLQDCVL LRFAQRIRLW LGKRGGELVE HFSLCFRRLL QLVPFVREAL LDVLTLLSLR
     RDSCLIVGLQ SLFITPKQLQ ANFLNHLDRL RNSNNDGRAD EQRLYSIEDT DRLIDEYQSY
     AKKTEEDFEA ANALKLRGEE LIETEEKELI GSITPKCQEL NRLTAQLDVA LRQRAQFLHS
     ARRLQNYISS ANQWCAAGVD LLTGASSMEF ESAEQCEAAL QRVRTFLKSG DEMCFDLDTS
     DSLLLLTSYD TKTLLDQRTT TAASIRERGF REPRSFKNLT APNFQVNARL TDVKQLCQNR
     CFFLKRLLSK TRSSAQSYSP FTESERIGMT LSGTYAPPAK GMQTSSSSPQ ASDTSEENAL
     PQSLTGGNLW SDMACFDDDG KSRCSSDSLP KRSAFVINEL VTTEQSYVDE LSSVLDHYVS
     AFDDPPTGCH LPSAVQAQRD ILFGNLAEIH QFHKVHFLPS LLRSSREGGA REIANAFLEH
     GDGLRCYVTY CLNKPKSDAL LRRHEQECHS FLKTCQERAG HGLPLGAYLL KPVQRITKYQ
     LLLKELARSS SLTEGRTDVE LALDAILYLL QQANASLNQG YIVGYTGDLS ALGPVLMEGS
     FRVSLSKRNG EKALRMRRGA KLRYRHVFLY SSLLLMCKHR RNSVPNAEER YEVKEELPVY
     SIEQVDMVKG KEGRFQVITE NRNETLTFSS SPDKVLQFVS KLKQLVEGCS SSFASSHHHR
     PISWTSHSSN ETGCIRVGER KRHSETDLLS RSVNGTTGGG ATSRYPLARS EHNLLRCFES
     AIHRSRSMDG HNVSKKEVKE TARICRDFVA KSRDHLSVVS GEAVIILNKR DKTDWTLVRS
     LQTQREGWVP AGHVQSTG
//