ID A0A085NIN1_9BILA Unreviewed; 931 AA.
AC A0A085NIN1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M514_10334 {ECO:0000313|EMBL:KFD69327.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD69327.1};
RN [1] {ECO:0000313|EMBL:KFD69327.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD69327.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KL367496; KFD69327.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085NIN1; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00089; Trypsin; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..931
FT /note="Cyclic nucleotide-binding domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001796031"
FT TRANSMEM 386..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..313
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 728..847
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT COILED 881..919
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 931 AA; 106180 MW; 7A41FC9CEFF5A67E CRC64;
MRNQQIEIVC AIFLLVINLH CTPTEETSPN CGNPYKHGGM VVQRYFIGKD SLKANPWTVM
IMKKKTKVVK CLGVLLPASE NSSSTVLTAS RCVKKSKKPN QGEYAIKVYY GATKLSPVVT
TGNKGQVRSH ANLNVSSDPS QDLALLFLRE PIIYNSSASP VCLGISKNVE RNEICYVSIF
THGMLTTMPA TVVPTFECTR NDIAKKMRED DICAKQLKSK DRVHVTVGDD TMYAREMATN
PEQYRRSMTA ASKRIEQPMD ADQNGHSSRL IGQTPSSEAI ERLPLENAER HPSAAGVAKT
LICIQNWLNR VERRRSTEGI RYDLAELVKS SSKDSLRSRK ESNASVVLNI GDPTAARLSS
LKKLAKQWAN KLFYETIDFK ETWYKIWLGI VTLTYLYNLV TIIARFSFYE LEEQLYSVWL
ALNYISDAVY LFDCYVELRL IFLERGMPVT DRRRVMKCNL RTKPFALSAM ASLPTDHIFR
LLPIPSSVVI LSRFNRLLRY NRVVQFVNFA ETETSMPNLF RTVQLMVIVY LIFHWATCFY
FLVSTAYGLE SDSWVYNSER ILDVTFDCAN STCRQPSEVV GTGTCGVIQY PLLLKHYLLC
LYWAALVLIS VGEQPFPIEI GQYLFTIVNF VAGTLILAGL IGNVRIVIAG MNQQRSTFRS
CFDGVKNFME MRKVNLELRK RVISWFTYVW EQKHAIIDED AVMAMLPMNL RTQLAIALHI
RTLRKANLFK DCDPGLLTEM ALKLKLQIFS PNDYICRKGE IGKDMYIVKQ GLLNVVADDG
VTVLVTLKEG SVFGELSIMD IPGNRNGNRR TTSVRSVGFS ELFALSKSDL FESLEKYPEA
KRLLLEKGRE ILRKDKLLIE HEPLPKNVFD FVEQEYDYES LNQLSRNIVS LKRQLAEKNT
QVKRTCDLTE QRVLQLEQNC RSNYCTWKEI Q
//
